Summary
Nicotinamide mononucleotide ("NMN" and "β-NMN") is a nucleotide derived from ribose and nicotinamide.Like nicotinamide riboside, NMN is a derivative of niacin, and humans have enzymes that can use NMN to generate nicotinamide adenine dinucleotide (NADH). Nicotinamide mononucleotide (NMN) is proved by Harvard scientists to reverse aging process and may be new alternatives to aging, type II diabetes, cancers, muscle wasting and inflammatory diseases within five to ten years.
Properties
Properties
IUPAC name: 3-Carbamoyl-1-[5-O-(hydroxyphosphinato)-β-D-ribofuranosyl]pyridinium
Other names: Nicotinamide ribonucleoside 5'-phosphate; Nicotinamide D-ribonucleotide;β-Nicotinamide ribose monophosphate; Nicotinamide nucleotide
CAS-No: 1094-61-7
Mol. Formula: C11H15N2O8P
Mol. Weight: 334.22
Product Detail
Mechanism of action
NMN increase the NAD+ level in the body.Then, all the modes of acts of NMN is to be the mechanism of NAD+. β-Nicotinamide mononucleotide is a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.
Application
Aging
NAD(+) levels were increased significantly both in muscle and liver by NMN
NMN-supplementation can induce similar reversal of the glucose intolerance
NMN intervention is likely to be increased catabolism of fats
NMN-supplementation does mimic exercise
DNA Damage
NMN was able to repair the DNA in cells damaged by radiation.
Neurological Injury
NMN treatment protects against cICH-induced acute brain injury
NMN treatment reduces brain cell death and oxidative stress
Further research
This has precipitated dozens of studies since that are focused on investigating
NMN supplementation to treat cardiovascular disease, diabetes, obesity, life extension,
cancer, Alzheimer’s disease, Parkinson’s disease, and many more.
Product List
|
Product Name |
Grade |
Purity |
Package |
|
Nicotinamide mononucleotide |
Food grade |
≥85% |
100g/ 1Kg/ 5Kg |
|
≥95% |
100g/ 1Kg/ 5Kg |
||
|
Reagent grade |
≥95% |
5g/25g |
|
|
Standard |
≥98% |
100mg |