Application Scenarios of Dipotassium Glycyrrhizinate

Dipotassium glycyrrhizinate (CAS: 68797-35-3), extracted from licorice, demonstrates anti-inflammatory, antioxidant, antibacterial, antiviral, and gastric mucosal protective properties, making it a versatile ingredient across industries. From eye drops and stomatitis ointments in pharmaceuticals to skin care, face creams in cosmetics, toothpaste in daily chemicals, and sweeteners, preservatives, and flavoring agents in food, its unique benefits are widely utilized.

 

 

 

 

Introduction to Dipotassium Glycyrrhizinate

 

CAS No.: 68797-35-3

EINECS number: 272-296-1

Molecular formula: C42H60K2O16

Molecular weight: 899.13

Physical properties:  It appears as a white powder with a sweet taste, soluble in water, glycerol, and propylene glycol, and slightly soluble in anhydrous ethanol and ether.

 

 

Dipotassium Glycyrrhizinate Efficacy

Moisturizing Capabilities

Dipotassium glycyrrhizinate functions as a potent moisturizer, assisting in preserving the skin's optimal moisture balance and guarding against dryness.

 

Calming & Anti-Allergic Properties

Furthermore, Dipotassium glycyrrhizinate offers soothing relief to sensitive skin and diminishes the likelihood of allergic reactions.

 

Natural Sweetening Agent

Additionally, Dipotassium glycyrrhizinate serves as a safe and efficient natural sweetener, boasting a sweetness level 80 to 100 times greater than sucrose.

 

Anti-Inflammatory & Anti-Allergic Benefits

A 0.5% solution of Dipotassium glycyrrhizinate exhibits an anti-inflammatory effect comparable to 0.1% dexamethasone, yet without the risk of severe adverse reactions.

 

Suppression of Protein Kinase Activity

It exerts its anti-inflammatory actions by inhibiting protein kinase activity, thereby blocking inflammatory signaling pathways.

 

Boosting Immune Function

Given its immunomodulatory properties, Dipotassium glycyrrhizinate effectively enhances the body's immune function.

 

Antispasmodic & Analgesic Effects

Moreover, it alleviates pain by diminishing the responsiveness of smooth muscle cells to neurotransmitters like acetylcholine, leading to smooth muscle relaxation.

 

 

Daily Chemical Industry Applications

- High-purity glycyrrhizic acid extract is seamlessly integrated into a wide array of daily chemical products, encompassing shower gels, facial cleansers, sunscreens, and facial creams, to elevate product efficacy and performance.

 

- Dipotassium glycyrrhizinate, leveraging its potent hyaluronidase inhibition capabilities, effectively retains hyaluronic acid, thereby dramatically enhancing skin hydration, elasticity, and anti-aging properties, making it an exemplary ingredient for daily skincare routines.

 

- Incorporating dipotassium glycyrrhizinate into skincare products effectively mitigates skin irritation triggered by cosmetic surfactants, ensuring a gentler and more comfortable daily skincare experience.

 

- Clinical trials have demonstrated that twice-daily usage of toothpaste containing 0.05% dipotassium glycyrrhizinate for a period of four weeks can significantly alleviate periodontal disease symptoms, with no adverse effects reported throughout the study.

 

- The innovative glycyrrhizic acid double salt exhibits vast potential in the daily chemicals sector. It boasts dual benefits of reducing inflammation, eliminating bacteria, and facilitating tissue healing, ushering in a new era of advanced personal care products.

 

- Given their capability to stably adjust pH levels within the range of 3.0-4.5, formulations incorporating dipotassium glycyrrhizinate as a thickener have emerged as favored components in cosmetics and personal care products, catering to the diverse demands of daily chemical applications.

 

- The catalytic prowess of dipotassium glycyrrhizinate in facilitating the hydrolysis of non-ionic ester surfactants, coupled with its remarkable stability and catalytic characteristics, portends vast potential for utilization in a myriad of daily chemical products.

 

- By exhibiting antiviral activity against Marek's disease virus through the induction of apoptosis in infected cells in an in vitro setting, dipotassium glycyrrhizinate presents novel antiviral avenues for incorporation into daily chemical applications.

 

 

Pharmaceutical Industry Applications

 

- Dipotassium glycyrrhizinate, a derivative of glycyrrhizic acid, has demonstrated immense potential in drug development owing to its anti-inflammatory, antiviral, and hepatoprotective attributes.

 

- Formulated as a mucoadhesive film, Dipotassium glycyrrhizinate exhibits notable potential in managing aphthous stomatitis, leveraging its exceptional adhesive properties, stretchability, and controlled drug release capabilities.

 

- Leveraging its physiological pH-regulating function, Dipotassium glycyrrhizinate finds extensive application in pharmaceutical solutions containing chlorolysozyme, as well as in topical formulations like eye drops, nasal sprays, and cosmetics.

 

- By virtue of its potent anti-inflammatory effect, Dipotassium glycyrrhizinate effectively modulates inflammatory processes, accelerating skin wound healing and opening new avenues for drug development.

 

- Dipotassium glycyrrhizinate boasts not only synergistic effects, safety, and efficacy but also shows promise in treating depression. As such, it can be incorporated daily as a component or synergist in antidepressant medications.

 

- Glycyrrhizic acid is employed in the formulation of drugs aimed at promoting myelin regeneration and inhibiting neurogenic inflammation, offering a potential therapeutic solution for demyelinating disorders and multiple sclerosis.

 

- As an agonist, inhibitor, or partial agonist, dipotassium glycyrrhizinate assumes a distinct role in the formulation and screening of TRPV1-associated medications, particularly in the realm of pain management.

- The integration of dipotassium glycyrrhizinate with sodium deoxycholate boosts cellular transportation across Caco-2 cell monolayers, potentially enhancing the absorption of poorly bioavailable compounds in pharmaceutical applications.

 

- The synergistic application of dipotassium glycyrrhizinate and acetaminophen not only mitigates the risk of liver injury but also augments the safety and efficacy profile of acetaminophen, offering an optimized therapeutic solution.

 

- Dipotassium glycyrrhizinate has demonstrated its potential to alleviate leptospira-induced nephritis in both in vitro and in vivo settings, presenting a novel therapeutic option for the treatment of nephritis and related conditions.

 

- By downregulating COX-2 protein expression and inflammatory markers, dipotassium glycyrrhizinate holds promise as a key component in the development of inflammatory pain relief medications, with notable peripheral analgesic effects.

 

- Leveraging its antiviral properties, dipotassium glycyrrhizinate is incorporated into pharmaceutical formulations containing DNA-ase, targeting infections caused by DNA viruses like herpes simplex, shingles, and human papillomavirus.

 

- Dipotassium glycyrrhizinate exhibits promising potential in the management of atopic dermatitis by diminishing AD-associated gene expression and cytokine production, instilling hope among AD patients.

 

- Derived from glycyrrhetinic acid, dipotassium glycyrrhizinate uniquely releases hydrogen sulfide, eliciting substantial anti-inflammatory effects without gastrointestinal tract compromise, rendering it suitable for the formulation of anti-inflammatory medications.

 

- Dipotassium glycyrrhizinate (DPG) reinforces snake venom adjuvant therapy through mitigating myonecrosis and fostering skeletal muscle regeneration, thereby enhancing its drug application versatility.

 

- Additionally, glycyrrhizic acid contributes to the development of medications aimed at safeguarding the intestinal epithelial mucosa, vital in preventing malnutrition-induced intestinal atrophy and degeneration.

 

 

Food Industry Applications

 

- Glycyrrhizic acid, renowned for its sweet flavor, frequently serves as a sucrose substitute in candies, beverages, ice cream, and other food products. Pure licorice extract candies boast the highest glycyrrhizic acid content at 23,154 mg/kg, while ice cream contains 1690 mg/kg, and brewed tea contains 1203 mg/L.

 

- In the realm of food science, natural surfactants, notably saponins, exhibit remarkable properties in constructing multiphase food systems. Glycyrrhizic acid, a food-grade and safe saponin, undergoes supramolecular self-assembly in aqueous environments, forming an ultra-fine, semi-flexible nanofiber network with exceptional gelling power and interfacial activity. These nanofibers' ability to precisely manipulate assembly at liquid interfaces and within the continuous phase positions them as an optimal material for crafting highly stable and processable multiphase food colloids.

 

 

 

References

1. Antonio Mascolo, et al. USE OF ONE OR MORE SALTS OF GLYCYRRHIZIC ACID FOR REDUCING THE IRRITATING ACTION OF SURFACTANTS IN COSMETIC COMPOSITIONS. mag (2009)

2. Susumu Tanaka, et al. Clinical Evaluation of the Dentifrice Containing TranexamicAcid and Dipotassium Glycyrrhizinate for Periodontal Disease.. JOURNAL OF DENTAL HEALTH (1991)

3. Misao Koide, et al. Catalytic effect of dipotassium glycyrrhizinate on the hydrolysis of nonionic ester surfactants. Journal of the American Oil Chemists' Society（1996）

4. Mônica Helena Monteiro do Nascimento, et al. Exploring the Pharmacological Potential of Glycyrrhizic Acid: From Therapeutic Applications to Trends in Nanomedicine. Future Pharmacology（2022）

5. Gye-Ju Rhee, et al. Formulation and Pharmaceutical Properties of Mucoadhesive Film Containing Dipotassium Glycyrrhizate. Journal of Pharmaceutical Investigation（1999）

6. Camila Dos Santos Leite, et al. Dipotassium Glycyrrhizininate Improves Skin Wound Healing by Modulating Inflammatory Process.. International journal of molecular sciences（2023）

7. Chuanlong Guo, et al. Enhanced corneal permeation of coumarin-6 using nanoliposomes containing dipotassium glycyrrhizinate: in vitro mechanism and in vivo permeation evaluation. RSC Advances（2015）

8. Tianbao Lv, et al. Dipotassium glycyrrhizinate relieves leptospira-induced nephritis in vitro and in vivo.. Microbial pathogenesis（2021）

9. Sung Hoon Lee, et al. Ameliorating effect of dipotassium glycyrrhizinate on an IL-4- and IL-13-induced atopic dermatitis-like skin-equivalent model. Archives of Dermatological Research（2018）

10. Gabriel Alves Bonafe, et al. Dipotassium Glycyrrhizinate on Melanoma Cell Line: Inhibition of Cerebral Metastases Formation by Targeting NF-kB Genes-Mediating MicroRNA-4443 and MicroRNA-3620-Dipotassium Glycyrrhizinate Effect on Melanoma. International journal of molecular sciences（2022）

11. Gabriel Alves Bonafé, et al. Growth Inhibitory Effects of Dipotassium Glycyrrhizinate in Glioblastoma Cell Lines by Targeting MicroRNAs Through the NF-κB Signaling Pathway.. Frontiers in cellular neuroscience（2019）

12. Thalita Rocha, et al. Glycyrrhizinate Dipotassium (DPG), Myonecrosis Control and Skeletal Muscle Differentiation: A New Adjuvant Therapy for Snake Envenomation. FASEB Journal（2017）

13. Shou-Yan Wu, et al. Research Progress On The Protective Effects Of Licorice-Derived 18 Beta-Glycyrrhetinic Acid Against Liver Injury. Acta pharmacologica Sinica（2021）

14. Qing Li, et al. Glycyrrhizic acid: self-assembly and applications in multiphase food systems. CURRENT OPINION IN FOOD SCIENCE（2022）

15. Nicolai Z. Ballin, et al. Glycyrrhizinic acid in licorice products on the Danish market. Food Control（2023）