Seebio® Offers Specialized APIs

At Seebio Biotech, we are dedicated to the development, production, and distribution of high-tech and distinctive APIs and intermediates. Our commitment to excellence is reflected in our ISO9001 certification for quality management. We take pride in advocating for superior APIs tailored for the pharmaceutical formulation sector, encompassing a range of APIs such as antibacterials, anti-inflammatories, and anti-allergy medications among others. Trust Seebio® for your API requirements.

Ketoconazole

CAS No.: 65277-42-1

Function: Ketoconazole, an imidazole antifungal medication, works by inhibiting the biosynthesis of ergosterol in fungal cell membranes. This disrupts the permeability of the cell membranes and curbs the growth of fungi. Ketoconazole is effective in treating both superficial and deep mycoses, including skin and nail fungus, vaginal candidiasis, gastrointestinal fungal infections, and more. It is also useful in combating systemic infections caused by fungi such as Candida albicans, coccidioids, and histoplasma.

Luliconazole

CAS No.: 187164-19-8

Function: Luliconazole is a new imidazole topical antifungal medication, which is an analog of lanoconazole. It works by inhibiting the activity of lanosterol demethylase, reducing the level of ergosterol, and interfering with the synthesis of fungal cell walls and the growth of fungi. Luliconazole is not only used to treat tinea pedis, jock itch, and tinea corporis, but it has also been developed for the treatment of onychomycosis (nail fungus).

Lanoconazole

CAS No.: 101530-10-3

Function: Lanoconazole is an imidazole antifungal drug, and its mechanism of action is similar to other imidazole drugs. It primarily inhibits the de14-methyl stage of 14-methyl lanosterol, aiming to prevent the synthesis of ergosterol in fungal cells, thereby exerting its antifungal effect.

Elubiol

CAS No.: 67914-69-6

Function: Elubiol, akin to the traditional imidazole antibacterial product ketoconazole, is a novel broad-spectrum antifungal agent of the imidazole class. It can inhibit the biosynthesis of fungal ergosterol and alter the composition of other lipid compounds in the cell membrane. Elubiol demonstrates antagonistic effects against Candida, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides, among others. However, unlike ketoconazole, which is not suitable for use in personal care products, Elubiol has better water solubility, making it an ideal choice for personal care products. It has been included in the range of personal care products used in Europe.

Efinaconazole

CAS No.: 164650-44-6

Function: Efinaconazole is the first topical triazole antifungal drug, developed for the treatment of local distal lateral subungual nail fungus (DLSO). This is one of the most common types of onychomycosis, where the pathogen first invades the distal subungual nail bed, leading to the thickening and keratinization of the nail bed. The nail plate may become white, brown, or grayish-brown, with a bumpy and dull surface, and may become fragile or even absent. Efinaconazole is effective in treating toenail fungus (onychomycosis).

Posaconazole

CAS No.: 171228-49-2

Function: Posaconazole is a powerful antifungal agent that prevents invasive fungal infections by inhibiting the biosynthesis of ergosterol. It is particularly useful for patients with invasive aspergillosis who are resistant to amphotericin B or itraconazole, or who cannot tolerate these medications. Clinically, posaconazole is employed for the treatment of aspergillosis, zygomycosis, and fusarium, as well as for certain fluconazole-resistant Candida infections.

Ravuconazole

CAS No.: 170864-29-6

Function: Similar to voriconazole, ravuconazole has a structure akin to fluconazole. Its pharmacological effects are identical to other azole drugs, with its inhibition of sterol C14 demethylation being comparable to that of itraconazole. In vitro experiments demonstrate its activity against fluconazole-resistant Candida glabrata and Candida kritrix, as well as Aspergillus, Actinomycetes, Fusarium, Coccidioides, Histoplasma, and other yeasts and molds. Additionally, it exhibits bactericidal activity against Aspergillus.

Erythromycin Lactobionate

CAS No.: 3847-29-8

Function: Erythromycin lactobionate is a macrolide antibiotic, specifically a water-soluble erythromycin lactionate. It possesses antibacterial activity against staphylococcal spp., streptococci, and gram-positive bacilli. Neisseria spp., Haemophilus influenzae, and Bordetella pertussis can also be sensitive to this compound. Furthermore, it exhibits antibacterial activity against various anaerobic bacteria, excluding Bacteroides fragilis and Fusobacterium spp. Additionally, it has inhibitory effects on Legionella spp., Campylobacter foetus, certain spirochetes, Mycoplasma pneumoniae, rickettsial spp., and Chlamydia spp.

Flurbiprofen

CAS No.: 5104-49-4

Function: Flurbiprofen, with the chemical name 2-fluoro-α-methyl(1,1’-diphenyl)-4-acetic acid, is a non-steroidal anti-inflammatory drug (NSAID). Clinically, it is indicated for the treatment of rheumatoid arthritis, osteoarthritis, and curved spondylitis, among others. Compared to similar drugs, flurbiprofen offers several advantages, such as a smaller dose, higher efficacy, faster onset of action, and fewer side effects.

Etoricoxib

CAS No.: 202409-33-4

Function: Etoricoxib is a highly selective cyclooxygenase-2 (COX-2) inhibitor, which is widely used in the treatment of various conditions, including osteoarthritis (OA), rheumatoid arthritis, ankylosing spondylitis, chronic low back pain, acute gouty arthritis, primary dysmenorrhea, and postoperative pain. As a non-steroidal anti-inflammatory drug, etoricoxib demonstrates anti-inflammatory, analgesic, and antipyretic effects in animal models.

Baricitinib

CAS No.: 1187594-09-7

Function: Baricitinib is an oral inhibitor of JAK kinases 1 and 2, commonly used in adults with moderately to severely active rheumatoid arthritis (RA). For patients with rheumatoid arthritis who have not previously used biologic DMARDs, baricitinib can reduce disease activity. Additionally, it is approved for the treatment of severe alopecia areata.

Desloratadine

CAS No.: 100643-71-8

Function: Desloratadine is the active metabolite of loratadine, obtained by the removal of the methoxyethyl group in the body. It is a third-generation antihistamine with strong anti-allergic properties, fast onset, and long-lasting effects. It exhibits affinity and selectivity for peripheral H1 receptors and is a novel treatment for seasonal allergic rhinitis and chronic urticaria.

Loratadine

CAS No.: 79794-75-5

Function: Loratadine is a second-generation, long-acting tricyclic antihistamine drug that is commonly used to treat allergies. It has a fast onset and strong effect without containing hormones. After being absorbed by the human body, it is metabolized into the more active desloratadine. By competitively inhibiting histamine H1 receptors, it prevents the allergic symptoms caused by histamine, without obvious anticholinergic or central inhibitory effects. Clinically, it is used to relieve symptoms associated with allergic rhinitis, such as sneezing, runny nose, and itchy nose, as well as itching and burning sensation in the eyes. It is also used to alleviate symptoms of chronic urticaria and other allergic skin diseases.

N-Methyl Desloratadine

CAS No.: 38092-89-6

Function: N-Methyl desloratadine is an intermediate in the synthesis of loratadine and can be used as an anti-allergic drug. Currently, loratadine, a second-generation tricyclic anti-allergic drug, is considered a first-line anti-allergic medication due to its high selectivity for peripheral H1 receptors, lack of side effects involving central and peripheral choline receptor inhibition, good clinical efficacy, and safe use.

Agomelatine

CAS No.: 138112-76-2

Function: Agomelatine is an antidepressant that acts as an agonist at melatonin receptors MT1 and MT2, and it is indicated for the treatment of major depressive episodes in adult patients. Agomelatine is both a melatonin MT1/MT2 receptor agonist and a serotonin 2C (5-HT2C) receptor antagonist. Through the synergistic effect of these two actions, it can restore the disordered biological rhythm of depressed patients to normal, producing an antidepressant effect. Its unique mechanism of action has opened up an innovative way to treat depression.

Erdosteine

CAS No.: 84661-23-4

Function: Erdosteine is a synthetic derivative in the form of N-thiolitones, derived from the natural amino acid methionine. It is a new type of mucolytic drug that can significantly reduce the viscosity of sputum and the level of fucose (a marker of mucus glycoprotein) in sputum. Additionally, it can reduce the dry weight of macromolecules in sputum and DNA levels in sputum. Erdosteine also increases the transport of mucocilia, enhancing its expectorant effect. Furthermore, it inhibits the effects of free radicals produced as a result of smoking. Clinically, it is mainly used for respiratory obstruction and mucus thickening caused by acute and chronic bronchitis, sinusitis, otitis, pharyngitis, and colds.