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Coenzyme NAD Series Products

Time:2024-02-23 Hits:238
In the biochemical diagnosis, the NAD-NADH and NADP-NADPH chromogenic systems play a crucial role. A common method for assessing the activity levels of numerous enzymes involves leveraging the variance in absorbance values at 340 nm between NAD-NADH and NADP-NADPH. Using lactic acid fermentation as an illustration:
 
 
Seebio offers a range of diagnostic-grade nicotinamide coenzyme products, encompassing NAD, NADH, NADP, and NADPH, among others.
 
 
Product Description
 
Nicotinamide coenzyme is the coenzyme of dehydrogenase and can be divided into oxidized and reduced forms.
 
1 NAD (oxidized coenzyme I)
 
English name: β-NAD+, β-Nicotinamide-adenine dinucleotide, oxidized form
Alias: β-Nicotinamide adenine dinucleotide (oxidized form)
CAS: 53-84-9
Molecular formula: C21H27N7O14P2
Molecular weight: 663.43
Structural formula:
 
2 NADH (reduced coenzyme I)
 
English name: β-NADH, β-Nicotinamide adenine dinucleotide, reduced disodium salt
Alias: reduced β-nicotinamide adenine dinucleotide disodium salt
CAS: 606-68-8
Molecular formula: C21H27N7Na2O14P2
Molecular weight: 709.4
Structural formula:
 
3 NADP (oxidized coenzyme II)
 
English name: β-NADP, β-Nicotinamide adenine dinucleotide phosphate
Alias: nicotinamide adenine dinucleotide phosphate
CAS:53-59-8
Molecular formula: C21H28N7O17P3
Molecular weight: 743.41
Structural formula:
 
4 NADPH (reduced coenzyme II)
 
English name: β-NADPH;β-Nicotinamide adenine dinucleotide 2’-phosphate reduced tetrasodium salt
Alias: Dihydronicotinamide adenine dinucleotide phosphate tetrasodium salt
CAS:2646-71-1
Molecular formula: C21H26N7Na4O17P3
Molecular weight: 833.35
Structural formula:
 
 
Principle of action
 
 
Taking NAD as an example, as shown in the figure, under the action of dehydrogenase, catalytic dehydrogenation is transferred to β-NAD+ to form reduced β-NADH. NADH has a characteristic absorption peak at 340nm, while NAD has no characteristic absorption peak at 340nm. Using its coupled dehydrogenase (tool enzyme) reaction, the concentration or activity of a substance can be measured based on the change in absorbance at 340nm. The same goes for NADPH and NADP.
 
Application areas
 
It can be used for the production of detection kits for ALT, AST, CK, LDH, CK-MB, α-HBDH, Glu, UREA, NH4+, CO2, etc.
 
 
Storage Conditions
Ice pack transport. Store at -20℃, valid for 2 years.
 
 
Product List
Item number
Product name
CAS number
Oxidized coenzyme I/beta-NAD
53-84-9
Reduced coenzyme I/beta-NADH disodium
606-68-8
Oxidized coenzyme II/beta-NADP
53-59-8
Reduced nicotinamide adenine dinucleotide tetrasodium phosphate (β-NADPH-4Na
2646-71-1
 
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