Acetyl Chitosamine: A Versatile Amino Sugar in Nature

Acetyl chitosamine, chemically designated as β-(1→4)-2-acetylamino-2-deoxy-D-glucose, is a pivotal amino sugar found abundantly in nature. It occurs naturally in numerous organisms, including shrimp and crab shells, as well as fungal cell walls. Acetyl chitosamine serves as a constituent of glycosaminoglycans and possesses a structural resemblance to articular cartilage tissue, making it highly beneficial for joint health. Across various skincare formulations, including lotions, creams, and facial masks, Acetyl chitosamine exhibits both moisturizing and whitening properties, thereby earning its widespread application.

 

 

 

CAS: 10036-64-3；7512-17-6

Molecular formula: C8H15NO6

Molecular weight: 221.21

Appearance : White or off-white powder

Melting point: 211 °C

Specific rotation: 42 º (c=2, water, 2 hrs)

Storage conditions: -20°C

Packaging specifications: 1kg 25kg (cosmetic grade, food grade)

 

 

Acetyl Chitosamine Efficacy

Moisturizing Effect: Acetyl chitosamine boasts exceptional moisturizing capabilities. It effectively absorbs and retains moisture, elevating skin hydration levels and ensuring the skin stays well-moisturized. Research has revealed that after four weeks of consistent use, Acetyl chitosamine can enhance skin hydration by up to 15%, thereby bolstering the skin's moisturizing capacity.

 

Reduction of Fine Lines: By stimulating collagen synthesis, Acetyl chitosamine aids in improving skin elasticity. This, in turn, minimizes the visibility of fine lines and wrinkles, resulting in a firmer, more youthful complexion.

 

Improvement of Pigmentation: Acetyl chitosamine exhibits the ability to inhibit tyrosinase activity, which subsequently reduces melanin production. This helps fade spots, alleviate uneven skin tone caused by UV exposure, and ultimately brighten the skin's overall appearance.

 

Natural Keratin Regulation: By interacting with the CD44 receptor, Acetyl chitosamine regulates the adhesion and metabolism of keratinocytes. This promotes the natural shedding of old keratin cells and maintains a healthy turnover of the skin's surface.

 

Whitening Effect: Clinical studies have demonstrated that the combination of 2% Acetyl chitosamine and 4% niacinamide exhibits a more pronounced effect in diminishing facial pigmentation and counteracting skin darkening induced by UV rays.

 

Antioxidant Properties: Acetyl chitosamine possesses the capability to scavenge free radicals, exemplified by its scavenging effect on DPPH, thereby aiding in the resistance against oxidative stress and safeguarding the skin from environmental damage.

 

Skin Repair: Thanks to its small molecular weight, Acetyl chitosamine can swiftly penetrate the skin, facilitating wound healing and exerting a repairing influence on the skin.

Skin Barrier Enhancement: It stimulates the synthesis of hyaluronic acid in skin epidermal cells, fortifying the skin barrier, minimizing water evaporation, and enhancing the skin's moisturizing capacity and resilience against external irritants.

 

 

Cosmetic Industry Application

Acetyl chitosamine stands out as an exceptionally effective moisturizer, boasting remarkable transdermal absorption capabilities and significantly enhancing the skin's hydration levels. Its ability to promote skin hydration has made it a staple ingredient in numerous cosmetic formulations. Furthermore, it is often combined with hyaluronic acid and sodium polyglutamate to bolster moisturizing properties and strengthen barrier repair functions.

 

In terms of skin whitening, acetyl chitosamine excels by inhibiting tyrosinase activity and reducing melanin synthesis, thereby improving facial pigmentation. It also synergizes with ingredients like niacinamide to amplify the whitening effect. Additionally, acetyl chitosamine possesses antioxidant properties, safeguarding the skin from free radical damage.

Within the multi-chitosan soothing composition, acetyl chitosamine collaborates with carboxymethyl chitosan, hydroxypropyl chitosan, and sophora bud extract to deliver outstanding moisturizing, redness-reducing, whitening, and repairing benefits. These ingredients interact in a synergistic, gentle, and non-irritating manner, making the composition ideal for skin care.

 

The application value of acetyl chitosamine in skin care product formulations is increasingly coming to the forefront. Research indicates that by refining the emulsification system, its dermal absorption efficiency can be markedly enhanced. This compound boasts not only superb moisturizing capabilities but also stimulates collagen synthesis, effectively addresses skin pigmentation issues, and accomplishes a multitude of skin care benefits.

 

Acetylchitosamine has demonstrated notable application value within the realms of cosmetics and dermatology. Research underscores its ability to significantly ameliorate skin conditions stemming from aging and external stressors, while positively influencing the health upkeep of nails and hair. Through tailored formulations, a range of aesthetic concerns and dermatological issues can be precisely targeted.

 

Formulations incorporating acetylchitosamine are primarily utilized in cosmetics and pharmaceuticals for skin exfoliation and hydration. Studies have validated its efficacy in fostering the renewal of the skin's stratum corneum while offering prolonged moisturizing effects. Often, additional synergistic amino sugar compounds are integrated into the formula to bolster the product's effectiveness.

 

Acetylchitosamine (NAGA) exhibits considerable potential in cosmetic applications via lipid-based nanoparticle (NLC) delivery systems. Drug-laden NLC was crafted using a thermal homogenization method and characterized through laser scattering, X-ray diffraction, and scanning electron microscopy. Clinical assessments reveal that this system not only elevates the dermal permeability of NAGA but also displays remarkable whitening effects in healthy subjects, effectively mitigating skin pigmentation issues.

 

Acetyl Chitosamine has secured the EU COSMOS organic certification for cosmetics, signifying its international acclaim in terms of safety.

 

 

Medical Field Application

Acetylchitosamine demonstrates distinctive benefits in managing hypertension. Clinical assessments have affirmed its safety and effectiveness in antihypertensive medications and health supplements, with negligible toxicity or adverse effects. This underscores its potential as a key active ingredient in the development of novel antihypertensive therapies.

Acetyl Chitosamine excels in addressing sexual dysfunction, boasting remarkable efficacy, a convenient formulation, and minimal side effects. These attributes position it as a significant therapeutic option in this medical domain.

 

Aetyl chitosamine has demonstrated remarkable efficacy in drug treatment for cardiac and cerebral ischemia. It significantly enhances survival rates in hypoxic conditions, substantially reduces cerebral edema and associated neurological symptoms, serving as a potent agent against ischemia and hypoxia-induced damage.

 

In the pharmaceutical and healthcare sectors, chitosamine is utilized in the development of drugs and products for varicose veins, offering high efficacy without toxic side effects. These medications and health supplements are specifically formulated to treat varicose veins, ensuring both effectiveness and safety. Additionally, chitosamine-based drugs have been designed to prevent, alleviate, and treat bedsores, proven to be non-toxic and highly therapeutic, effectively managing and mitigating bedsore symptoms.

 

In the realm of pharmaceutical anti-tumor research, acetylchitosamine has achieved significant breakthroughs. From laboratory research to animal studies and human clinical trials, it has consistently shown notable anti-tumor activity. Notably, in the treatment of metastatic diseases, through refined dosage regimens, it has exhibited promising clinical outcomes, presenting a novel option for tumor therapy.

 

Acetylchitosamine has also proven effective in treating non-specific inflammation induced by physical or chemical factors. Clinical studies reveal that this compound not only effectively controls inflammatory symptoms but also demonstrates excellent safety, with no significant side effects observed. This combination of efficacy and safety makes acetylchitosamine an ideal candidate for the treatment of non-specific inflammation.

 

The composition of acetyl chitosamine is extensively utilized across skin regulation, immune enhancement, and tissue growth applications. It fosters anti-aging effects, accelerates wound healing, and encourages stem cell maturation. This versatile ingredient not only addresses skin conditions and combats aging but also speeds up wound recovery and triggers signals that promote stem cell growth.

 

Regarding acetyl chitosamine, its efficacy in treating local damage and symptoms resulting from viral or bacterial infections stands at an impressive 90% among related medications, demonstrating outstanding therapeutic outcomes. It effectively addresses local damage while alleviating various infection-related symptoms.

 

In cancer research, acetylchitosamine has exhibited promising anti-cancer potential. Through rigorous experimentation at animal, cellular, and molecular levels, it has been established that it augments the efficacy of TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) in treating non-small cell lung cancer. Studies indicate that this synergistic mechanism significantly enhances tumor cell sensitivity to TRAIL, offering a novel approach to lung cancer treatment.

 

Additionally, acetylchitosamine serves as an adjunctive therapy for perianal diseases by stabilizing cellular lysosomes. This action accelerates tissue healing and guards against infection. In the management of perianal diseases, it not only promotes tissue recovery but also effectively wards off infection.

 

 

New Material Applications

In drug sustained-release systems, acetyl chitosamine serves as a carrier material, forming a hydrogel with specific drug release characteristics when compounded with other components like Poloxamers. This composite hydrogel boasts not only impressive drug loading capacity but also the ability to regulate the drug release rate by tailoring its physicochemical properties.

 

Polyacetylchitosamine exhibits outstanding properties in the realm of biomedical materials. It can be processed into various forms, such as fibers and films, through wet or dry spinning processes. Its exceptional enzymatic degradation performance and hydrolytic stability render it ideal for the production of absorbable surgical sutures and other surgical supplies, promising broad application prospects within the medical device industry.

 

Polyacetylchitosamine has found widespread use in the medical field as an innovative hemostatic agent. Chemical composition analysis, spectroscopic technology, and electron microscopy characterization have confirmed its unique β-tertiary structure and exceptional biocompatibility. Hemostatic dressings, exemplified by SyvekPatch and RDH, have demonstrated significant effectiveness in controlling bleeding during surgical procedures and trauma situations.

 

As a polymer derived from acetylchitosamine, chitin has demonstrated remarkable therapeutic effects in practical applications. Studies have shown that utilizing different dosage forms, such as chitin sponges, cotton pads, sheet materials, and chitin-NWF, can effectively address symptoms associated with trauma, abscesses, surgical defects, and hernias. Clinical data reveals that 89.5% of cases using chitin sponges achieved favorable healing outcomes, with no adverse reactions reported in any of the cases.

 

 

Food Application

Acetylchitosamine exhibits unique worth in managing food allergies and sensitivities. Research has validated that regular therapeutic doses of acetylchitosamine supplementation can effectively uphold the integrity and functionality of the gastrointestinal barrier, leading to substantial alleviation of food allergy symptoms. This revelation unearths fresh avenues for application within the health food and dietary supplement industries.

 

 Acetylchitosamine has garnered considerable attention as a functional sweetener in the food and beverage sector. Beyond its sweetening properties, studies have revealed its notable anti-inflammatory and analgesic effects. This multifaceted attribute grants it a distinctive edge in the development of functional foods.

 

Acetylchitosamine holds immense value as an additive in wine production. Experiments have confirmed its ability to reduce harmful substances (including alcohol) in wine by over 95%, thereby significantly enhancing wine's food safety. This discovery offers a novel technological means to upgrade wine quality and safeguard consumer health.

 

As a beer additive, acetylchitosamine offers substantial health benefits. Research has validated its ability to significantly reduce the adverse effects of harmful substances (including alcohol) in beer, achieving a control efficiency exceeding 95%. This groundbreaking discovery presents novel approaches to enhancing the healthfulness and safety of beer products.

 

 

Use Cases

The Qianjirou brand has introduced an essence product formulated with Acetyl chitosamine, which also incorporates a blend of other ingredients like niacinamide, hydrolyzed hyaluronic acid, sodium hyaluronate, and more. These components synergistically deliver a multitude of benefits, including moisturizing, antioxidant protection, anti-glycation, and skin firming. Additionally, the product contains 1,2-hexanediol for hydration, p-hydroxyacetophenone as an antioxidant, glycerin for moisturizing, and tranexamic acid for soothing. In essence, Qianjirou Acetyl chitosamine essence is a facial essence focused on moisturizing and repair.

OZZIESU Glucosamine Essence, apart from featuring the active ingredient Acetyl chitosamine, also comprises niacinamide (serving as a moisturizer and antioxidant), carnosine (moisturizing and antioxidant), parahydroxyacetophenone (antioxidant), and hexylene glycol (moisturizer). Acetyl chitosamine primarily functions as a moisturizer and skin conditioner in this essence, providing hydrating and repairing benefits. The essence primarily targets moisturizing and antioxidant protection, while also offering repair and anti-glycation effects.

 

Repinax Acetyl Chitosamine Gel features Acetyl Chitosamine as a key component, complemented by a blend of other ingredients like panthenol and sodium hyaluronate. Together, they offer a multitude of benefits, including moisturization, antioxidation, soothing, and anti-aging properties. Additionally, the gel contains moisturizers like 1,2-hexanediol, as well as film formers and emulsion stabilizers such as acrylic acid (esters)/vinyl isodecanoate crosspolymer, making it an all-inclusive skincare solution.

 

The CERBEB brand has introduced a lightweight, water-based product infused with Acetyl Chitosamine. It boasts a variety of ingredients, including butylene glycol, niacinamide, hydrolyzed sodium hyaluronate, and 1,2-hexanediol for intense moisturization. Parahydroxyacetophenone provides antioxidant protection, while sodium hyaluronate offers soothing, anti-aging, and repairing benefits alongside moisturization. Glycerin further enhances moisturization, and tranexamic acid contributes a soothing effect. Ingredients like propylene glycol, dipotassium glycyrrhizinate, and glyceryl glucoside also play roles in moisturizing and soothing. The formula also includes mussel extract, oligopeptide-1, sodium heparin, and sodium DNA, which offer antioxidant, soothing, repairing, and anti-aging properties. In summary, CERBEB Acetyl Chitosamine Water-Light Liquid is a moisturizing and repairing skincare product with additional antioxidant and soothing benefits.

 

Huaneng has launched a product called Huaneng Cinderella Acetyl Chitosamine Calcium Water. This lotion/toner contains various ingredients, including calcium chloride for thickening, skin conditioning, and viscosity control. It also includes hydroxyethyl urea, trehalose, dipotassium glycyrrhizate, sodium PCA, and 1,2-hexanediol for moisturization. Parahydroxyacetophenone acts as an antioxidant, while disodium EDTA serves as a chelating agent. These ingredients work synergistically to provide the product with moisturizing, astringent, soothing, and antioxidant properties.

 

 

References

 

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