Polysucrose (CAS number 26873-85-8), known by the trade name Ficoll, is a polymer derived from sucrose and epichlorohydrin, subsequently purified through ultrafiltration or fractional precipitation. Characterized by a highly branched structure, abundant hydroxyl content, excellent solubility in aqueous solutions, and notable biodegradability and biocompatibility, polysucrose finds extensive applications in biomedicine, pharmaceuticals, and related fields. Its raw material, sucrose, being a renewable and cost-effective resource with high purity, contributes to its widespread use.
In comparison to dextran, polysucrose exhibits a more spherical structure and less flexibility. Gel permeation chromatography (GPC) analysis of polysucrose and dextran fractions of similar molecular weights reveals that polysucrose has a smaller hydrodynamic volume, leading to a longer retention time. Notably, polysucrose is more sensitive to acidic conditions than dextran, necessitating caution when working at acidic pH levels.
Ficoll 70
Polysucrose 70, a water-soluble polymer compound, demonstrates exceptional solubility and stability. Its favorable water solubility, stability, and rheological properties contribute to its widespread utilization in the food, pharmaceutical, cosmetic, and other industries.
Applications
Food Industry:
Polysucrose 70 serves as a thickener, stabilizer, emulsifier, and lubricant in the food industry. Its capacity to enhance viscosity and refine taste makes it valuable in products like ice cream, desserts, and beverages. Additionally, it acts as a carrier for food flavors, improving stability and flavor persistence.
Pharmaceuticals:
In the pharmaceutical field, Polysucrose 70 is a key component in oral drugs, eye drops, creams, gels, and other preparations. It enhances drug solubility and bioavailability, increases viscosity and stability, thereby improving the overall effectiveness of the drug. For instance, it is employed in capsule formulations to elevate viscosity and enhance stability and taste.
Cosmetics:
Polysucrose 70 finds application in cosmetics as a thickener, emulsifier, stabilizer, and lubricant. Its ability to increase viscosity, enhance stability, and impart gloss makes it suitable for lotions, shampoos, conditioners, shower gels, and other products. The inclusion of Polysucrose 70 improves texture and enhances the overall user experience.
