Nicotinamide mononucleotide (NMN)

Properties

IUPAC name: 3-Carbamoyl-1-[5-O-(hydroxyphosphinato)-β-D-ribofuranosyl]pyridinium
Other names: Nicotinamide ribonucleoside 5'-phosphate; Nicotinamide D-ribonucleotide;β-Nicotinamide ribose monophosphate; Nicotinamide nucleotide

CAS-No: 1094-61-7
Mol. Formula: C11H15N2O8P
Mol. Weight: 334.22

Mechanism of action
NMN increase the NAD+ level in the body.Then, all the modes of acts of NMN is to be the mechanism of NAD+. β-Nicotinamide mononucleotide is a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.

Application

Aging

NAD(+) levels were increased significantly both in muscle and liver by NMN

NMN-supplementation can induce similar reversal of the glucose intolerance

NMN intervention is likely to be increased catabolism of fats

NMN-supplementation does mimic exercise

DNA Damage

NMN was able to repair the DNA in cells damaged by radiation.

Neurological Injury

NMN treatment protects against cICH-induced acute brain injury

NMN treatment reduces brain cell death and oxidative stress

Further research

This has precipitated dozens of studies since that are focused on investigating

NMN supplementation to treat cardiovascular disease, diabetes, obesity, life extension,

cancer, Alzheimer’s disease, Parkinson’s disease, and many more.

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