The number of unsaturated isoprenoid chains on the side chain of the Vitamin K2 are varied, they are usually referred to as MK-n in brief, in which n represents the number of isoprenoid chain. The active forms of vitamin K2 are MK-7, MK-4 and MK-9.
The biological activity of vitamin K2 surpasses that of vitamin K1, primarily owing to its elongated side chain. This extended structure enables vitamin K2 to circulate in the bloodstream for a longer duration, thus facilitating its effective reach to various body parts.
Vitamin K2 plays a pivotal role in regulating blood calcium levels, directing calcium towards bones rather than its accumulation in blood vessels or soft tissues. This regulation is crucial for the prevention of conditions such as osteoporosis and arteriosclerosis.
In the normal metabolism of human body, when the gastrointestinal function is in the normal state, the normal intestinal flora will the participate in the transformation from vitamin K1 or K3, K4 to vitamin K2 living body, and then they can be absorbed by the body.
【MK-4 Properties】：
Appearance: pale yellow to yellow crystal powder/oil.
Melting point: 33-37℃
Solubility: Easily soluble in n-hexane, soluble in ethanol, slightly soluble in methanol, almost insoluble in water
MK-4（Reference JP14/JP15 technical index）
CAS: [11032-49-8] or [863-61-6]
Mol. Formula: C31H40O2
Mol. Weight: 444.65
Shelf life: 2 years
Dangerous grade: Non-hazardous
Grade: Equivalent to JP 14/CP2005
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Art.No.
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Specification
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MOQ
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DCF0004A
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0.13%Oil
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5-100kg
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DCF0004B
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0.13% powder (sustained released preparation)
|
10kg
|
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DCF0004C
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1.3% Oil
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1-5kg
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DCF0004D
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1.3% powder (sustained released preparation)
|
1kg
|
|
DCF0004E
|
98% powder
|
1kg
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【MK-4 Function】：
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Treat and prevent osteoporosis, bone protein can be generated by Vitamin K2 and then co-generate bone with calcium. Vitamin K2 can increase bone density and prevent fractures.
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Vitamin K2 can prevent cirrhosis from developing to liver cancer.
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It can treat vitamin K2 deficiency hemorrhagic disease, promote the formation of prothrombin, accelerate blood clottingand maintain normal clotting time.
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It has the function of diuretic and improving the liver's detoxification.
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High dietary menaquinone intake is associated with reduced coronary calcification
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A high menaquinone intake reduces the incidence of coronary heart disease
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Dietary intake of menaquinones is associated with reduced risk of coronary heart disease: the Rotterdam Study
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vitamin K consumption is associated with cardio-metabolic disorders
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Latest science study results showed that severe aortic calcification and the relative risk of CHD mortality was reduced with vitamin K2.
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Vitamin K2 reduces nighttime leg cramps in the elderly and muscle spasms in blood dialysis patients.
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Latest research findings indicate that vitamin K2 reduces inflammation through multiple mechanisms, including increasing anti-inflammatory fatty acid concentrations and decreasing inflammatory precursor fatty acid concentrations.
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Vitamin K2 produced by gut microbiota, through the gut-brain axis, has a positive impact on cognition and neural health.
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Increasing intake of vitamin K2 helps lower health risks associated with calcium deposition.
【MK-4 Application】：
It can be used as anti-osteoporosis drugs or nutraceuticals.
Vitamin K2 can be used as raw materials of health care product or nutrition fortifier;
It can be added to general public food as a special food additive;
