Sodium Caseinate for Colloidal Gold Immunochromatography

Sodium caseinate (CAS#9005-46-3) is employed as a critical component in colloidal gold immunochromatography to mitigate false positives by binding to non-specific sites.

 

 

 

Introduction to Sodium Caseinate 

Casein sodium salt (CAS#9005-46-3) is the sodium derivative of casein, derived from the latter. Casein, predominantly found in animal milk, especially in cow's milk, constitutes approximately 80% of the protein content. It forms a soluble calcium phosphate complex with a micellar structure and is classified into four types: α-, β-, γ-, and κ-casein.

 

 

Basic Information

Alias: Sodium caseinate

CAS: 9005-46-3

 

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Physical and Chemical Properties

Sodium caseinate is a white or milky-white powder with no distinct odor, tasteless or possessing a mild specific aroma and taste. It easily dissolves or disperses in water, with a pH value ranging from 6.0 to 7.5. When its aqueous solution encounters acidity, casein precipitates. Notably, there is no agglomeration when heated at 94°C for 10 seconds or 121°C for 5 seconds.

 

 

Application in Colloidal Gold Immunochromatography

Interference with Electrostatic Interactions: Sodium caseinate, functioning as a protein, interferes with electrostatic interactions. This unique property allows it to bind to non-specific sites in colloidal gold immunochromatography, effectively eliminating false positives.

 

Dispersion and Colloidal Stability: Sodium caseinate, when dispersed in a solution, exerts a repulsive effect on the gold-labeled complex. This repulsion increases the degree of dispersion, acting as a framework for dispersing colloidal gold particles and thereby maintaining colloidal stability in the immunochromatography process.

 

 

Other Applications of Sodium Caseinate:

Nutritional Studies on Litopenaeus vannamei Larval Feeds: Casein-based feeds, incorporating sodium caseinate, were formulated to investigate the nutritional effects of vitamin E on Litopenaeus vannamei larval feeds.

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Enzyme Activity Determination:  The activity of three enzyme solutions containing trypsin, chymotrypsin, and peptidase was assessed, likely utilizing sodium caseinate in relevant assays.

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Nitrogen Metabolism Studies in Holstein Cattle: Sodium caseinate was employed to study the effects of bovine growth hormone (BST) administration and abomasal casein infusion on nitrogen metabolism in Holstein cattle.

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Component of Blocking Solution in Immunoblots: Sodium caseinate serves as a component in the blocking solution for immunoblots, aiding in preventing nonspecific binding during antibody incubation.

 

 

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