Tocopheryl Acetate: A Potent Antioxidant for Youthful Skin

Tocopheryl acetate (CAS: 7695-91-2), a derivative of vitamin E, is recognized for its potent antioxidant properties and is commonly used in cosmetics. Due to its oil-solubility and nourishing characteristics, it effectively moisturizes the skin, strengthens connective tissues, protects against UV radiation, promotes wound healing, reduces inflammation, and enhances skin texture.

 

Tocopheryl acetate exhibits low safety risks, making it a popular ingredient in a wide range of skincare products. Its versatility and market value are underscored by its ability to serve multiple functions in cosmetic formulations, contributing to both skin health and product stability.

 

 

 

Basic product information

 

CAS No.: 7695-91-2

Molecular formula: C31H52O3

Molecular weight: 472.74

EINECS Number: 231-710-0

 

 

 

Benefits of Tocopheryl Acetate

 

Antioxidant Effect

Tocopheryl acetate possesses strong antioxidant properties, effectively neutralizing free radicals and inhibiting lipid peroxidation. This action helps the skin combat excessive oxidative stress caused by external factors such as UV rays and air pollution, thereby delaying photoaging and protecting against skin damage.

 

Anti-Inflammatory Effects

This compound also exhibits anti-inflammatory properties, helping to reduce inflammation, alleviate pain, and promote wound healing. It achieves this by stabilizing cell membrane structures and minimizing the release of inflammatory mediators.

 

Cardiovascular Health Protection

Thanks to its antioxidant capabilities, tocopheryl acetate can prevent damage to vascular endothelial cells, lower blood lipid levels, and improve blood circulation, contributing to overall cardiovascular health.

 

Moisturizing Effect

Tocopheryl acetate promotes the renewal of epidermal cells and enhances skin barrier function, resulting in effective moisturization and improved skin hydration.

 

Delaying Aging

By slowing down the cellular aging process through its antioxidant effects, tocopheryl acetate helps delay the visible signs of aging, promoting a youthful appearance.

 

 

Daily Chemical Applications

 

- Tocopheryl acetate is commonly applied topically in cosmetics, demonstrating excellent moisturizing properties and strengthening the skin barrier.

 

- Widely utilized in both cosmetics and medicinal products, tocopheryl acetate serves as a moisturizing and therapeutic agent, effectively addressing skin issues such as dermatitis, acne, burns, and ulcers.

 

- Due to its remarkable antioxidant and skin-conditioning properties, tocopheryl acetate is often included in cosmetic formulations at concentrations of up to 5%. It is recognized as a safe ingredient for cosmetic use.

 

- The incorporation of tocopheryl acetate and its derivatives in cosmetics, dermatological treatments, and pharmaceutical compositions helps protect the skin against free radicals and their detrimental effects.

 

- The successful encapsulation of tocopheryl acetate in a Pickering emulsion system enhances its stability and antioxidant activity, broadening its potential applications in cosmetics due to improved solubility.

 

- Transfectants containing tocopherol, as an applied form of tocopheryl acetate, contribute to skin regeneration owing to their in vitro antioxidant activity.

 

- Alpha-tocopheryl acetate, when applied topically in bulk formulations, has demonstrated significant benefits for various skin conditions due to its moisturizing and antioxidant capabilities.

 

- Applying a 20% tocopheryl acetate spray to dry hair, followed by massage and a resting period before rinsing, can effectively combat head lice infestations.

 

- Tocopheryl acetate gradually releases active vitamin E into the skin, providing excellent UV protection even in small amounts as part of a daily skincare routine.

 

- Topical application of tocopheryl acetate can achieve a tocopherol conversion rate of 4.52-5.97%, with a side skin conversion rate between 5.0-6.01%, demonstrating its effective absorption and conversion by the skin.

 

- In addition to its moisturizing and skin barrier-strengthening properties, tocopheryl acetate shows positive effects in treating various skin diseases, including dermatitis, eczema, acne, and wounds.

 

- This innovative formula contains 20-70% tocopheryl acetate, making it suitable for topical use in a hydrophobic gel, with antioxidant properties that promise potential benefits for the skin.

 

 

Medical Applications

 

- Applying tocopheryl acetate significantly enhanced neurobehavioral activity and lessened oxidative damage in mice exposed to cigarette smoke, suggesting it could potentially protect neuronal health.

 

- Topical formulations containing tocopheryl acetate have proven quite beneficial when used as excipients in skin products like ointments, creams, and gels.

 

- Using tocopherol acetate to treat diabetes successfully normalized lipid peroxidation, lowered total lipid levels, and raised plasma levels, demonstrating its positive effect on the lipid profile of diabetic patients.

 

- Applying tocopherol acetate promoted the maintenance of hematopoietic stem cells by attenuating oxidative phosphorylation and boosting the G0 phase in CD34+ cells, opening up new possibilities for in vitro stem cell manipulation.

 

- Tocopherol acetate serves as an internal standard for the UV-derivatized spectrophotometric analysis of coenzyme Q10, which effectively improves the accuracy of determining coenzyme Q10 content in drug and plasma samples.

 

- Topical tocopherol acetate shows great promise in delaying wound healing by stimulating granulation tissue growth, inhibiting bacterial proliferation, regulating angiogenesis, and enhancing epithelialization.

 

- Topically applying tocopherol acetate rarely causes allergic contact dermatitis and is safer when combined with glycyrrhetinic acid, as case studies have shown.

 

- Compared to traditional ointments, topical tocopheryl acetate demonstrates improved safety and efficacy in treating neonatal skin lesions in the NICU, promoting faster recovery and reducing treatment failure rates and costs.

 

- The child received intravenous tocopherol acetate at 4.5 mg/kg daily for 5 days, which significantly raised serum tocopherol levels to the normal range with no complications observed.

 

 

Delivery Media Applications

 

- The inclusion of idebenzone in tocopherol acetate lipid nanoparticles significantly enhancing their antioxidant properties and effectively mitigated skin pigmentation, underscoring the superior photoprotective expertise of this topical formulation.

 

- Tocopherol acetate nanoemulsions, formulated with a sophisticated lipid-polymer emulsifier blend, exhibit optimized dermal delivery, drastically enhancing the skin's absorption of active ingredients.

 

- Tocopherol acetate is innovatively encapsulated within waxy corn starch microcapsules, facilitating controlled release of active components. Its diffusion rate is intimately tied to the polymer matrix's free volume, thereby enhancing the delivery efficiency of bioactive compounds.

 

- As the liquid lipid constituent in lipid nanoparticles co-encapsulating idebenzone, tocopherol acetate showcases immense potential for crafting novel, antioxidant-driven delivery systems aimed at treating diverse ailments.

 

- To maximize loading capacity, tocopherol acetate can be formulated in powdered form, synergistically paired with adsorbents like microcrystalline cellulose. Furthermore, the incorporation of magnesium carbonate notably augments adsorption efficiency, rendering this preparation more potent in application.

 

- A stable ethanol gel, enriched with tocopheryl acetate, has been devised. This formulation was strategically crafted to enhance transdermal permeation, hinting at a promising avenue for topical applications of tocopheryl acetate in the future.

 

 

Feed Farming Applications

 

- tramuscular injections of DL-tocopheryl acetate into growing lambs positively influence collagen and decorin proteins within their bodies, potentially enhancing meat quality without compromising growth rates or carcass aesthetics, including tenderness.

 

- Accurate quantification of tocopheryl acetate and tocopherol in aquatic organisms and fish feed underscores their pivotal role in aquaculture. Furthermore, it elucidates their expansive utility in aquatic nutrition evaluation and quality control applications.

 

- Incorporating tocopheryl acetate into the diets of common carp juveniles significantly boosts their growth rates, survival rates, and immune defenses against Aeromonas in aquatic environments. This not only slashes production costs but also elevates the overall wellbeing of your fish.

 

- Experimental findings from topical applications of tocopherol acetate and tocopherol on pig skin reveal that these compounds and their metabolic derivatives are efficiently converted into active antioxidant forms, thereby markedly augmenting the skin's antioxidant capacity.

 

 

Scientific Research and Applications

 

- Upon topical application to the skin of hairless mice, tocopheryl acetate is efficiently absorbed and transformed into active tocopheryl, demonstrating notable photoprotective effects under UV-B exposure. This underscores its potential as a skin protectant.

 

- Research conducted on mice exposed to cigarette smoke reveals that tocopheryl acetate administration significantly mitigates lung pathology and oxidative stress, hinting at its protective capacity against smoke-induced lung injury.

 

- Investigations into Tetrahymena thermophila reveal that exposure to tocopherol acetate leads to reduced growth rates, downregulation of the FLP1 gene, and diminished feeding behavior. These observations suggest that tocopheryl acetate may exert detrimental effects on normal cellular physiology.

 

- Naturally occurring tocopherol acetate is identified in the secretions of the southern wind beetle. Notably, its primary function does not directly target the organism but serves as a carrier molecule in defensive actions. This discovery offers a novel lens through which to examine biological defense mechanisms.

 

 

Food Applications

 

- Tocopheryl acetate, commonly referred to as tocopherol acetate, plays a pivotal role in ensuring the quality and safety of food products within the food industry. Its reputation stems from its potent immune-modulating capabilities and exceptional antioxidant properties. The rigorous purity standards adhered to underscore its esteemed position in the realm of food science.

 

 

- The chemical stability of tocopherol acetate is influenced by a multitude of environmental factors, among them being moisture content, temperature variations, and shifts in pH levels. When navigating the production processes of food and health supplements, the meticulous selection of the most compatible form and formulation becomes paramount in optimizing product quality. This decisive step ensures that the beneficial properties of tocopherol acetate are preserved and harnessed to their fullest potential.

 

 

New Material Applications

 

- The utilization of MALDI-IMS (Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry) technology for visual analysis vividly showcases how tocopherol acetate is effectively sequestered within the confines of the polymer film. This advanced technique establishes a robust foundation for delving into the intricate migration pathways and distribution patterns of substances within laminated films, emerging as a potent tool in this field.

 

- During the rubber vulcanization and anti-aging processes, the incorporation of tocopherol in quantities ranging from 0.01% to 1% markedly accelerates vulcanization efficiency and optimizes the aging coefficient. This synergistic effect comprehensively elevates the overall performance of rubber materials, endowing them with enhanced durability and stability. As a result, tocopherol provides a formidable guarantee for the longevity and reliability of rubber products.

 

 

Cosmetic Examples

 

L'Oréal has unveiled Kiehl's Ultra-Refreshing Gel Cream, a revolutionary product fortified with tocopheryl acetate, a dual-action humectant and antioxidant that retains skin moisture and mitigates free radical damage. This innovative formula further incorporates 1,2-pentanediol, another humectant, and Pseudoalteromonas ferment extract, renowned for its hydrating and oil-regulating properties. Additionally, Biosaccharide Gum-1, a soothing humectant, contributes to the overall comfort and well-being of the skin.

 

Winona has introduced a transparent sunscreen enriched with tocopheryl acetate, offering both moisturizing and antioxidant benefits to the skin. This advanced formulation also boasts a trio of hydrating ingredients—glycerin, propylene glycol, and butylene glycol—alongside chemical sunscreens like methylene bis-benzotriazolyl tetramethylbutylphenol, ensuring comprehensive UV protection. Furthermore, the inclusion of flat-core wood oil and purslane extract enhances the product's moisturizing, antioxidant, and soothing capabilities, further improving the skin's hydration and calmness.

 

Piara has launched Makeup Locking Loose Powder 01 Natural, a makeup staple infused with tocopheryl acetate, which safeguards skin moisture and shields against free radical harm. This powder also features Shea Butter, a skin conditioner renowned for its moisturizing, soothing, and anti-aging properties. Additionally, 1,2-Hexanediol, a humectant, aids in maintaining the skin's optimal moisture balance, ensuring a flawless, long-lasting finish that cares for your skin.

 

Skynfuture has unveiled an innovative skin whitening cream, formulated with tocopherol acetate, a powerful agent that stimulates skin metabolism and alleviates dryness. This advanced cream boasts a blend of other meticulously chosen ingredients, including glyceryl polyacrylate for thickening and film-forming, 1,2-hexanediol as a hydrating agent, and sodium chloride, serving dual roles as an oral care aid and emulsifier stabilizer. Furthermore, the cream is enriched with phenylethyl resorcinol, glycyrrhizin, carnosine, and sodium hyaluronate, among other active ingredients, each contributing to its multifaceted benefits like antioxidant protection, freckle reduction, whitening, hydration, soothing, anti-aging, and skin repair.

 

Baiyunshan has launched an eye anti-wrinkle plant extract essence oil, a luxurious formulation tailored for the delicate eye area. This eye essence oil is a harmonious blend of various potent ingredients, foremost among them tocopheryl acetate, which not only nourishes but also safeguards the skin with its antioxidant properties. Additionally, Damascus rosa flower oil adds a layer of hydration and emollience, while 1,2-hexanediol, another hydrating ingredient, collaborates with these to deliver a profound moisturizing and anti-aging effect, leaving the eye skin looking refreshed and rejuvenated.

 

 

References

 

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