Inositol: Versatile Benefits from Skincare to Overall Health
Time：2024-09-04 Hits：496
Inositol (CAS: 87-89-8) is a vital nutrient found abundantly in both animal and plant sources, particularly in organ meats and various plants. Resembling a vitamin, inositol plays a crucial role in cellular signaling, lipid metabolism, and insulin regulation. In the personal care industry, inositol is prized for its exceptional hydrating, antioxidant, and cell-repairing properties, making it a popular ingredient in skincare and personal care products. In the food industry, it is used as a functional ingredient in dietary supplements, functional beverages, and fortified foods to enhance their health benefits. The pharmaceutical industry is also increasingly exploring inositol’s potential therapeutic applications for various health conditions.
Product Introduction
CAS No.: 87-89-8
Molecular formula: C6H12O6
Molecular weight: 180.16
EINECS number: 201-781-2
|
Product Name
|
Aliases
|
CAS
|
Level
|
Packaging
|
|
Inositol
|
Cyclohexanehexol
|
87-89-8
|
Daily chemical grade, food grade, pharmaceutical grade
|
1kg 25kg
|
|
Sodium Inositol Hexaphosphate
|
Sodium Phytate
|
14306-25-3
|
Daily chemical grade, food grade
|
1kg 25kg
|
Benefits of Inositol
Daily Use: In cleansers, inositol helps retain skin moisture and promotes a healthy glow. It is also included in serums and masks, where it nourishes the skin and protects it from environmental stress.
Cell Protection and Repair: Inositol plays a vital role in cell protection and repair, supporting essential physiological functions in the body.
Enhances Insulin Sensitivity: By improving insulin sensitivity and reducing insulin resistance, inositol is particularly beneficial for women with PCOS. It helps regulate menstrual cycles, improve ovarian function, and boost fertility.
Liver Protection: Inositol protects the liver, reduces the risk of fatty liver disease, improves transaminase levels, and enhances the activity of glutathione peroxidase.
Lowers Blood Lipids: It aids in converting cholesterol into bile acids in the liver, lowering blood cholesterol and lipid levels, and helping to prevent atherosclerosis and cardiovascular diseases.
Antioxidant and Anti-inflammatory: With its antioxidant and anti-inflammatory properties, inositol helps alleviate muscle fatigue and improve sleep quality.
Nervous System Support: Inositol is essential for maintaining intracellular ion balance, which is key to normal nerve cell excitability and conduction.
Improves Reproductive Health: In assisted reproductive technology, myo-inositol enhances the quality of eggs and sperm, increasing the success rates of in vitro fertilization.
Gestational Diabetes Management: Inositol effectively lowers blood glucose levels and reduces the risk of gestational diabetes.
Applications in the Daily Chemical Industry
- As an active ingredient in cosmetics, inositol enhances the oxygenation of skin cells and promotes tissue metabolism, improving overall skin health and vitality.
- In skincare formulations, inositol is focused on boosting cellular oxygenation and metabolic efficiency, driving advancements in cosmetic products aimed at optimizing skin health and appearance.
- Myo-inositol derivatives in skincare products offer superior moisturizing properties and significant skin health benefits, highlighting the promising potential for myo-inositol in the cosmetics industry.
- In practical applications, myo-inositol derivatives enhance the performance of topical skincare products, providing a silky texture while significantly improving hydration and overall skin health.
- The use of a four-enzyme mixture to produce high-concentration myo-inositol through microencapsulation presents transformative opportunities and significant economic potential for skincare and haircare products in the cosmetics industry.
Food Industry Applications
- Myo-inositol is widely used in the food and health products sector, particularly for its anti-aging benefits, which include delaying muscle deterioration and enhancing age-related exercise capacity. This provides a solid scientific foundation for healthy aging strategies.
- As an innovative functional ingredient, inositol fatty acid ester excels in fat metabolism-regulating foods and medications. It is easily absorbed and hydrolyzed into myo-inositol and fatty acids within the body, delivering the benefits of myo-inositol without increasing fat accumulation risk.
- Produced through the fermentation of plant proteins by specific microorganisms, inositol is extensively applied in food, animal feed, and food additives, showcasing its rich biological properties and significant potential for enhancing product value.
- Myo-inositol and its derivatives play an important role in the pharmaceuticals, cosmetics, food, and feed industries due to their diverse functions and broad applications. They bring new vitality to sectors focused on health, beauty, and nutrition.
- Agriculturally derived myo-inositol has gained attention in the pharmaceutical and food industries, especially for its benefits in managing diabetes and polycystic ovary syndrome (PCOS). As a dietary supplement, it offers promising strategies for preventing and managing these conditions.
- Research shows that appropriate supplementation of myo-inositol during pregnancy—specifically 2g twice daily—is safe and effective, significantly reducing the risk of gestational diabetes and preterm birth, thereby safeguarding maternal and fetal health.
Pharmaceutical Industry Applications
- Myo-inositol is widely used in treating conditions such as polycystic ovary syndrome (PCOS), gestational diabetes mellitus (GDM), male fertility issues, and diseases affecting steroidogenesis, highlighting its crucial role in endocrine and reproductive health.
- In reproductive medicine, myo-inositol is essential for gamete development and embryo formation. Its ability to enhance fertility, optimize oocyte quality, and support healthy embryo development is key to advancements in assisted reproductive technology.
- Myo-inositol’s role in cell signaling suggests its potential in treating neurodegenerative diseases (e.g., the role of scyllo-inositol) and diabetes (the role of D-chiro-inositol).
- Inositol's biomedical applications, such as regulating insulin signaling, resisting oxidative stress, and delaying cognitive decline, make it a promising agent for maintaining health and slowing the aging process.
- Inositol’s versatility is evident in its effectiveness in addressing mental health disorders, metabolic abnormalities, and PCOS, indicating its broad application potential in reproductive medicine, neurology, and various therapeutic interventions.
- Inositol’s central role in cell membrane construction, neural signaling, and lipid transport, along with its involvement in signaling cascades and functional derivative synthesis, underscores its importance in cell and molecular biology research.
- Its effectiveness in managing insulin homeostasis, treating PCOS and diabetes, and preventing gestational diabetes highlights inositol’s critical role in metabolic regulation and pregnancy health.
- The potential of inositol and its derivatives in preventing and treating alcoholic liver disease and non-alcoholic steatohepatitis offers new therapeutic approaches for liver disease management.
- Myo-inositol’s positive effects on spermatogenesis and D-chiro-inositol’s role in reducing testosterone, particularly when combined with antioxidants, provide new strategies for improving male fertility.
- Inositol inhibits tumor growth through multiple mechanisms, including modulating key signaling pathways, blocking the cell cycle, reducing inflammation, and remodeling the cytoskeleton, demonstrating its potential as a broad-spectrum anticancer agent.
- Inositol has shown promising results in treating PCOS, addressing infertility, regulating menstrual cycles, improving metabolic health, and enhancing overall fertility, offering new hope for those with polycystic ovary syndrome.
- Myo-inositol’s potential as an animal growth promoter sheds light on its role in influencing cell signaling, promoting growth, and optimizing fat metabolism, providing new insights for livestock development.
- The combined use of myo-inositol and probiotics has shown significant benefits in enhancing insulin sensitivity, preventing and treating type II diabetes, preventing cardiovascular diseases, and improving overall insulin sensitivity.
- As an adjunctive treatment for bipolar depression, myo-inositol crosses the blood-brain barrier and influences neurotransmitter receptor properties, offering a new perspective on depression treatment.
- The multi-target anticancer effects of myo-inositol and its derivatives, such as inositol hexaphosphate, which modulate signaling pathways like PI3K/AKT, MAPK, PKC, AP-1, and NF-κB, while reducing chemotherapy side effects, bring new hope for cancer treatment.
- Myo-inositol’s role in regulating thyroid function, restoring normal thyroid status, reducing autoantibodies, and inhibiting thyroid cancer cell proliferation provides a new option for treating thyroid disorders.
- Inositol’s positive impact on enhancing reproductive function in PCOS patients and improving reproductive health in those undergoing antiretroviral therapy, particularly the potential of D-chiro-inositol to improve oocyte quality, offers new avenues for treatment.
- The potential of inositol derivatives in treating diseases associated with abnormal protein folding or amyloid deposition opens new pathways for tackling these challenging conditions.
- Inositol has shown multiple potential applications in dental medicine, including its anti-inflammatory properties, antibacterial effects on biofilms, and potential value in endodontic treatments, restorative dentistry, implant designs, and oral hygiene products, offering new strategies for preventing and treating dental diseases.
Agricultural Applications
- In the agricultural sector, myo-inositol is emerging as a potential plant biostimulant, notably enhancing zinc absorption in wheat, which can effectively increase grain zinc content and optimize nutrient uptake and in vivo transport efficiency.
- In plants, myo-inositol plays a dual role: during the seed stage, it serves as the primary component of phytic acid, protecting seed germination. In parenchymal tissues, it converts into free inositol, participating in the regulation of plant growth and development, highlighting its potential value in plant physiology.
- Myo-inositol has shown significant potential in promoting cell division and plant regeneration in cabbage protoplast cultures. This provides a basis for improving cabbage varieties through somatic cell hybridization technology, enhancing their quality and offering new scientific approaches.
- When combined with agricultural waste, such as corn soaking liquid, myo-inositol significantly improves the growth performance and salt tolerance of cabbage under saline stress conditions. This reveals its potential in agricultural stress management, offering new solutions for mitigating the adverse effects of soil salinity on crops.
- The multifaceted role of phosphoinositides in agriculture is noteworthy. They are vital for breeding low-phytate crops and effectively using phytase in animal nutrition, contributing to reducing the environmental impact of animal manure and showcasing their diverse agricultural value.
- Inositol also shows broad prospects in animal nutrition, particularly in enhancing rumen function, promoting microbial diversity, and regulating the metabolite composition of ruminants. These benefits are significant for improving animal health and production performance, further underscoring its potential in sustainable agriculture.
New Material Applications
- The development of trivalent metal cis-inositol complexes marks an innovative application in pharmaceutical compositions, particularly in iron therapy for anemia, showcasing the broad potential of these materials in medical treatments.
- New inositol-based materials are extending their application scope to drug design, facilitating the effective delivery of drugs to therapeutic targets and treating diseases related to abnormal cell signaling mediated by phosphatidylinositol and its derivatives, opening new pathways for disease treatment.
- Inositol is particularly useful in preparing anti-inflammatory drugs by targeting the cytotoxic effects of reactive oxygen species during inflammation. It offers excellent efficacy, minimal side effects, a straightforward synthesis process, and convenient administration, making it a promising option for treating inflammatory diseases.
- Inositol NF is considered a highly promising chewable tablet excipient due to its excellent hygroscopic properties, pleasant mouthfeel, and superior ability to mask the unpleasant taste of drugs, significantly enriching the diversity of drug formulations and patient acceptability.
- A new inositol combination precisely regulates the activity of B and T lymphocytes in mammals, exhibiting potent immunomodulatory effects applicable to autoimmune diseases and post-transplantation immune regulation, providing new molecular targets and strategies for treating immune-related diseases.
- The synergistic effect of inositol and ionic liquids shows broad potential in drug delivery systems, new material synthesis, and green solvent development, opening diverse opportunities for scientific research and technological advancement, and promoting continuous innovation in related fields.
Cosmetics Cases
Beirun® RELLET Hyaluronic Acid Inositol Emulsion utilizes inositol as one of its active ingredients, offering moisturizing, anti-aging, and firming effects. The product also contains ingredients such as butylene glycol, caprylic/capric triglyceride, glycerin, and macadamia seed oil, which together provide multiple benefits, including hydration, soothing, and antioxidation.
Bojing® Inositol Firming Night Essence Eye Cream features inositol as a core ingredient, combining moisturizing, anti-aging, and skin-tightening effects. It also includes ingredients like glycerin (humectant), polydimethylsiloxane (hair conditioning agent and emollient), butylene glycol (humectant), and allantoin and sodium hyaluronate (humectants and soothing agents). The cream offers moisturizing, antioxidant, soothing, and repairing effects, with added fragrances and plant extracts such as macadamia seed oil, gentian extract, and propolis extract for skin conditioning.
Dongyanyue® Yeast Softening Cream contains inositol, which serves as a moisturizer, antistatic agent, skin penetrant, and skin conditioning agent, providing moisturizing, anti-aging, and firming benefits. The product also includes squalane (moisturizer and emollient), sodium hyaluronate (moisturizer with soothing and anti-aging effects), and sodium polyglutamate (moisturizer and anti-wrinkle agent), offering comprehensive skin care benefits.
References:
1. Mauro Vieira de Almeida ,et al. A cascata dos fosfoinositídeos. QUIMICA NOVA（2003）
2. Oliver C Watkins ,et al. A review of the role of inositols in conditions of insulin dysregulation and in uncomplicated and pathological pregnancy. Critical reviews in food science and nutrition（2022）
3. Hirobumi ,et al. A skin care and cosmetic preparation containing an inositol derivative. mag（2005）
4. Ivana Vucenik ,et al. Anticancer Properties of Inositol Hexaphosphate and Inositol: An Overview.. Journal of nutritional science and vitaminology（2019）
5. Ana Druzijanic ,et al. Application of Inositol Hexaphosphate and Inositol in Dental Medicine: An Overview. Biomolecules（2023）
6. Annarita Stringaro ,et al. Application of myo-inositol and d-chiro-inositol in andrological issues. A Clinical Guide to Inositols（2023）
7. Mariano Bizzarri ,et al. Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate.. International journal of endocrinology（2016）
8. Hirobumi Aoki ,et al. External Preparation for Skin and Cosmetic Containing Inositol Derivative. mag（2007）
9. Jelena Karanović ,et al. Inositol – A natural treatment for polycystic ovarian syndrome?. Acta Medica International（2016）
10. S.A. Lee ,et al. Inositol - An effective growth promotor?. World's Poultry Science Journal（2016）
11. P. Malangeau ,et al. Inositol et scyllitol dans les végétaux alimentaires. Plant Foods for Human Nutrition（1958）
12. Amerigo Vitagliano ,et al. Inositol for the prevention of gestational diabetes: a systematic review and meta-analysis of randomized controlled trials. Archives of Gynecology and Obstetrics（2018）
13. S S Nasir ,et al. Inositol N.F.: New Excipient for Chewable Tablets. Journal of Pharmaceutical Sciences（1966）
14. Raijindra Aneja ,et al. Inositolphospholipids and analogues: phosphatidylinositol products and processes. mag（2011）
15. Simona Dinicola ,et al. Inositols: From Established Knowledge to Novel Approaches.. International journal of molecular sciences（2021）
16. Ivana Vucenik ,et al. Multitarget Activities of Inositol and Inositol Hexakisphosphate. Approaching Complex DiseasesHuman Perspectives in Health Sciences and Technology（2020）
17. Daniele Barbaro ,et al. Myo-inositol for subclinical hypothyroidism and potential prevention of thyroid tumors. A Clinical Guide to Inositols（2023）
18. Andrea Etrusco ,et al. Myo-inositol in assisted reproductive technology from bench to bedside. TRENDS IN ENDOCRINOLOGY AND METABOLISM（2024）
19. Eunyee Jie ,et al. Myo-inositol increases the plating efficiency of protoplast derived from cotyledon of cabbage (Brassica oleracea var. capitata). Journal of Plant Biotechnology（2011）
20. Mariangela Palmieri ,et al. Myoinositol: from gametes to embryonic development. Computers & Chemical Engineering（2016）
21. Yunjie Li ,et al. Production of myo-inositol: Recent advance and prospective. Biotechnology And Applied Biochemistry（2022）
22. Sayeree Joardar ,et al. Recent advances in myo-inositol recovery and purification from agricultural sources as potential dietary supplements: A review. SUSTAINABLE CHEMISTRY AND PHARMACY（2023）
23. Dirk Blunk ,et al. Syntheses, amphitropic liquid crystallinity, and surface activity of new inositol-based amphiphiles.. Langmuir : the ACS journal of surfaces and colloids（2009）
24. Antonio J. Lopez-Gambero ,et al. The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases. Biomedicines（2020）
25. Zhi-Xu Zhang ,et al. The First Chiro-Inositol Organosilicon Ferroelectric Crystal.. Angewandte Chemie（2022）
26. Astrit M. Gashi ,et al. Therapeutic potential of inositol to PCOS: An overview of administration, efficacy, and potential applications. Romanian Medical Journal（2024）