Application of PEGylation in Recombinant Protein Drugs
Time：2023-11-17 Hits：419
Seebio provides a wide variety of PEGs from phospholipid PEGs to fluorescent PEGs with a complete product portfolio. It also has the capability for contract development and manufacturing (CDMO/CRO) of recombinant protein drug intermediates.
PEG Modification of Proteins[1]
Recombinant proteins are obtained using recombinant DNA or RNA technology to connect gene fragments that can be translated into the desired protein to recombinant vectors. They are the core products in biologics and have significantly higher safety compared to small molecule drugs. Although the production conditions are harsh, the administration procedures are complex, and the prices are expensive, they have irreplaceable therapeutic effects on certain diseases and thus have relatively high approval rates. At the same time, the clinical trial period of recombinant protein drugs is shorter than that of small molecule drugs, with relatively extended patent protection, which gives pharmaceutical companies more exclusive profit time. These features have become an important motivator for the R&D of recombinant protein drugs.
Production Process of Recombinant Protein Drugs[1]
Using chemical modification and genetic engineering technologies to transform or modify recombinant protein drugs to address issues like short half-life in blood, single administration route, immunogenicity and side effects, thereby enhancing drug activity and improving efficacy, is one of the focuses in recombinant protein drug research. Long-acting protein biologics technology is also a core technology occupied by many large international companies.
Polyethylene glycol (PEG), due to its low immunogenicity, good water solubility and biocompatibility, is the most widely used polymer in biomedicine. Its "stealth" effect is the "gold standard" of biomaterials. The main PEG modification methods for protein drugs are amino modification (including N-terminal amino acylation modification, lysine side chain amino acylation modification, N-terminal amino alkylation modification), carboxyl modification, thiol modification, etc. Currently, research on PEG-modified protein drugs is mainly focused on adenosine deaminase, asparaginase, interferon, granulocyte colony stimulating factor, interleukin, etc.
CAS# N/A
TZ-Ste-SO2-nBu-AEEA-Glu(OH)- Glu(OH)-AEEA-Lys(OH)-C |
CAS# 1188328-37-1
OtBu-Ara-Glu(AEEA-AEEA-OH)-OtBu |
CAS# N/A
HO-Ste-CYH-Glu(OH)-Glu(OH)-AEEEEA-Mal |
|
After PEG covalent modification, the half-life of protein drugs is prolonged, immunogenicity is reduced, while maximally retaining its bioactivity, thus improving efficacy:
Molecular radius is increased, renal clearance rate is decreased.
PEG forms a shielding and steric hindrance effect on the protein surface, reducing the enzymatic degradation rate and increasing stability and half-life.
The shielding and steric hindrance effects can also mask antigenic sites on the protein surface, reducing the immunogenicity of the protein.
Increases the solubility of the drug in body fluids.
The chemical bond with the drug hydrolyzes over time in vivo, slowly releasing the drug[2].[2]。
Various types of PEGylated proteins[3]
Currently, R&D giants in recombinant protein drugs (Amgen, Biogen IDEC, Johnson & Johnson, Eli Lily, Novo Nordisk, Roche) are almost all from Europe and America[4], accounting for about 80% of the global market share. The sales of all European and American companies account for as high as 97% of the sales of global biotechnology companies. Since the approval of the first PEGylated protein drug, Adagen (PEG-ADA) for treatment of severe combined immunodeficiency syndrome by FDA in 1990, many other drugs have also been approved successively.
PEGs-modified protein approved FDA. Site-specific PEGylated proteins given in bold[3]
FDA Approved PEGylated Protein Drugs
Reference:
1.Y. Wei, Z.W. Zhang, et al. Chin j Biotech, 2018, 34(3): 360-368
2.K.J. Dozier, D.M. Distefano Int. J. Mol. Sci. 2015, 16(10), 25831-25864(扉页图片)
3.F.M. Veronese, G. Pasut. Drug Discov.Today, 2005, 10(21): 1451–1458
4.W.X. Wu, Y. Zhang, et al. Lett Biotechnol, 2006, 17(6): 929–934.
Seebio PEGylation Product List
| Product NO. | CAS | Product Name | Size 1 | Size 2 | Purity |
| AAU0205A | 876345-13-0 | Boc-NH-PEG4-CH2COOH | 250mg | 500mg | 97% |
| AAU0206A | 951671-87-7 | DNP-PEG3-azide | 100mg | 200mg | 98% |
| AAU0207A | 112-35-6 | m-PEG3-OH | 100g | 200g | 97% |
| AAU0208A | 756525-95-8 | NH2-PEG2-C2-Boc | 1g | 2g | 95% |
| AAU0209A | 581065-95-4 | Amino-PEG4-Boc | 1g | 2g | 97% |
| AAU0210A | 1393330-38-5 | Bromo-PEG4-acid | 1g | 2g | 97% |
| AAU0211A | 139115-90-5 | Azido-PEG2-alcohol | 1g | 2g | 97% |
| AAU0212A | 86520-52-7 | Azido-PEG3-alcohol | 5g | 10g | 98% |
| AAU0213A | 305372-39-8 | Biotin-PEG2-Mal | 100mg | 200mg | 98% |
| AAU0214A | 1453117-42-4 | Tos-PEG4-acid | 1g | 2g | 97% |
| AAU0215A | 86259-87-2 | BnO-PEG4-OH | 25g | 50g | 97% |
| AAU0216A | 1312309-63-9 | Azido-PEG2-C2-acid | 1g | 2g | 97% |
| AAU0217A | 1446282-18-3 | Amino-PEG5-Boc | 2g | 4g | 98% |
| AAU0218A | 252881-74-6 | NH2-PEG3-C2-Boc | 2g | 4g | 97% |
| AAU0219A | 1393330-36-3 | Bromo-PEG1-C2-Boc | 1g | 2g | 97% |
| AAU0220A | 928292-69-7 | Amino-PEG10-amine | 1g | 2g | 97% |
| AAU0221A | 890091-43-7 | Boc-amido-PEG9-amine | 1g | 2g | 97% |
| AAU0222A | 1859379-85-3 | Propargyl-PEG2-acid | 5g | 10g | 98% |
| AAU0223A | 906099-89-6 | Biotin-PEG6-alcohol | 1g | 2g | 97% |
| AAU0224A | 1800414-71-4 | Azido-PEG11-amine | 1g | 2g | 97% |
| AAU0225A | 31127-85-2 | Bis-PEG4-acid | 1g | 2g | 98% |
| AAU0226A | 518044-37-6 | Mal-PEG6-Boc | 250mg | 500mg | 97% |
| AAU0227A | 437655-95-3 | Fmoc-NH-PEG4-CH2COOH | 5g | 10g | 98% |
| AAU0228A | 1122484-77-8 | NH2-PEG2-C1-Boc | 1g | 2g | 97% |
| AAU0229A | 144942-89-2 | Amino-PEG1-C2-acid | 5g | 10g | 98% |
| AAU0230A | 127828-22-2 | Amino-PEG2-NH-Boc | 1g | 2g | 98% |
| AAU0231A | 166388-57-4 | Azido-PEG2-C2-amine | 250mg | 500mg | 97% |
| AAU0232A | 149299-82-1 | Hydroxy-PEG2-CH2-Boc | 1g | 2g | 97% |
| AAU0233A | 1233234-77-9 | Boc-NH-PEG11-NH2 | 100mg | 200mg | 97% |
| AAU0234A | 208827-90-1 | Propargyl-PEG3-alcohol | 5g | 10g | 97% |
| AAU0235A | 287174-32-7 | Hydroxy-PEG1-CH2-Boc | 1g | 2g | 97% |
| AAU0236A | 756525-93-6 | Mal-amido-PEG8-NHS ester | 250mg | 500mg | 98% |
| AAU0237A | 1008402-79-6 | Bis-PEG9-NHS ester | 25mg | 50mg | 98% |
| AAU0238A | 756526-04-2 | NH2-PEG9-acid | 3g | 6g | 98% |
| AAU0239A | 1191079-83-0 | Amino-PEG9-acid | 1g | 2g | 97% |
| AAU0240A | 872679-70-4 | Fmoc-NH-PEG2-CH2CH2COOH | 10g | 20g | 98% |
| AAU0241A | 882847-13-4 | Boc-NH-PEG6-CH2CH2COOH | 100mg | 200mg | 97% |
| AAU0242A | 1334169-93-5 | Boc-NH-PEG8-CH2CH2COOH | 100mg | 200mg | 97% |
| AAU0243A | 756525-91-4 | Boc-NH-PEG4-CH2CH2COOH | 100mg | 200mg | 97% |
| AAU0244A | 1347750-78-0 | Boc-NH-PEG5-CH2CH2COOH | 100mg | 200mg | 97% |
| AAU0245A | 1312309-64-0 | N3-PEG2-C2-NHS ester | 100mg | 200mg | 97% |
| AAU0246A | 439114-13-3 | Bis-PEG5-acid | 1g | 2g | 97% |
| AAU0247A | 875770-34-6 | Biotin-PEG3-azide | 1g | 2g | 97% |
| AAU0248A | 31576-51-9 | m-PEG2-Amine | 1g | 2g | 98% |
| AAU0249A | 1383814-00-3 | Amino-PEG12-Boc | 1g | 2g | 98% |
| AAU0250A | 929-75-9 | Amino-PEG3-C2-Amine | 1g | 2g | 95% |
| AAU0251A | 142929-49-5 | Boc-NH-PEG1-CH2COOH | 1g | 2g | 97% |
| AAU0252A | 937188-59-5 | Hydroxy-PEG4-acid | 100mg | 200mg | 97% |
| AAU0253A | 663171-32-2 | Biotin-PEG4-amine | 250mg | 500mg | 98% |
| AAU0254A | 169751-72-8 | Hydroxy-PEG4-CH2-Boc | 1g | 2g | 97% |
| AAU0255A | 2100306-71-4 | Bromo-PEG3-CH2-Boc | 1g | 2g | 98% |
| AAU0256A | 459426-22-3 | Biotin-PEG4-NHS ester | 250mg | 500mg | 97% |
| AAU0257A | 2055042-66-3 | Hydroxy-PEG9-Boc | 250mg | 500mg | 98% |
| AAU0258A | 108466-89-3 | Boc-NH-PEG2-CH2COOH | 1g | 2g | 97% |
| AAU0259A | 215181-61-6 | m-PEG2-azide | 5g | 10g | 97% |
| AAU0260A | 86770-67-4 | Azido-PEG4-alcohol | 1g | 2g | 97% |
| AAU0261A | 1895922-74-3 | Boc-NH-PEG2-propargyl | 250mg | 500mg | 97% |
| AAU0262A | 87450-10-0 | Propargyl-PEG4-alcohol | 100mg | 200mg | 95% |
| AAU0263A | 9004-74-4 | m-PEG-OH (MW 2000) | 25g | 50g | 97% |
| AAU0264A | 57641-66-4 | Bromo-PEG2-alcohol | 5G | 10G | 97% |
| AAU0265A | 54149-17-6 | m-PEG2-Br | 5g | 10g | 97% |
| AAU0266A | 27425-92-9 | m-PEG10-alcohol | 1g | 2g | 97% |
| AAU0267A | 2101563-45-3 | Fmoc-NH-PEG10-acid | 1g | 2g | 97% |
| AAU0268A | 1257063-35-6 | Azido-PEG4-C2-acid | 250mg | 500mg | 97% |
| AAU0269A | 462100-06-7 | Boc-NH-PEG3-CH2COOH | 1g | 2g | 97% |
| AAU0270A | 869310-84-9 | Propargyl-PEG2-NHBoc | 250mg | 500mg | 97% |
| AAU0271A | 858126-78-0 | DNP-PEG4-NHS ester | 500mg | 1g | 97% |
| AAU0272A | 518044-31-0 | Hydroxy-PEG3-CH2-Boc | 1g | 2g | 97% |
| AAU0273A | 297162-47-1 | Hydroxy-PEG6-CH2-Boc | 1g | 2g | 97% |
| AAU0274A | 955094-26-5 | Mal-amido-PEG2-NHS ester | 250mg | 500mg | 97% |
| AAU0275A | 1404111-67-6 | N-Boc-PEG5-alcohol | 1g | 2g | 97% |
| AAU0276A | 186020-66-6 | Hydroxy-PEG3-(CH2)2-Boc | 10g | 20g | 97% |
| AAU0277A | 791028-27-8 | Amino-PEG2-C2-acid | 20g | 40g | 97% |
| AAU0278A | 165963-71-3 | N-Boc-PEG3-bromide | 1g | 2g | 97% |
| AAU0279A | 1334177-79-5 | Mal-amido-PEG6-acid | 1g | 2g | 97% |
| AAU0280A | 2241669-16-7 | NH2-PEG5-C6-Cl (hydrochloride) | 1g | 2g | 97% |
| AAU0281A | 557756-85-1 | Fmoc-NH-PEG4-CH2CH2COOH | 5g | 10g | 98% |
| AAU0282A | 474082-35-4 | Amino-PEG9-amine | 1g | 2g | 98% |
| AAU0283A | 119189-70-7 | Bis-PEG6-acid | 250mg | 500mg | 97% |
| AAU0284A | 2388521-20-6 | Hydroxy-PEG12-Boc | 250mg | 500mg | 98% |
| AAU0285A | 361189-64-2 | Hydroxy-PEG6-Boc | 250mg | 500mg | 97% |
| AAU0286A | 164332-88-1 | N-Boc-PEG2-bromide | 1g | 2g | 97% |
| AAU0287A | 929-59-9 | Bis-NH2-PEG2 | 25g | 50g | 95% |
| AAU0288A | 1818294-42-6 | Amino-PEG10-Boc | 100mg | 200mg | 97% |
| AAU0289A | 1334177-80-8 | Cbz-NH-PEG6-C2-acid | 250mg | 500mg | 97% |
| AAU0290A | 957486-82-7 | Azido-PEG6-amine | 250mg | 500mg | 97% |
| AAU0291A | 1334177-87-5 | Cbz-NH-PEG8-C2-acid | 100mg | 200mg | 95% |
| AAU0292A | 361189-66-4 | Azido-PEG6-acid | 500mg | 1g | 98% |
| AAU0293A | 1670249-37-2 | Azido-PEG9-acid | 500mg | 1g | 98% |
| AAU0294A | 39160-70-8 | Amino-PEG6-alcohol | 250mg | 500mg | 97% |
| AAU0295A | 2093153-98-9 | Propargyl-PEG9-amine | 100mg | 200mg | 97% |
| AAU0296A | 882518-90-3 | Azido-PEG2-CH2COOH | 250mg | 500mg | 97% |
| AAU0297A | 756526-00-8 | Cbz-NH-PEG4-C2-acid | 250mg | 500mg | 97% |
| AAU0298A | 1245823-51-1 | Propargyl-PEG5-acid | 1g | 2g | 98% |
| AAU0299A | 1425973-14-3 | NH2-PEG7 | 500mg | 1g | 98% |
| AAU0300A | 1347760-82-0 | Propargyl-PEG3-acid | 250mg | 500mg | 97% |
| AAU0301A | 1951438-84-8 | Propargyl-PEG6-acid | 250mg | 500mg | 97% |
| AAU0302A | 932741-19-0 | Propargyl-PEG3-amine | 1g | 2g | 97% |
| AAU0303A | 34188-11-9 | NH2-PEG5-OH | 250mg | 500mg | 98% |
| AAU0304A | 581065-94-3 | Tos-PEG5-Boc | 1g | 2g | 97% |
| AAU0305A | 86770-68-5 | Azido-PEG5-alcohol | 250mg | 500mg | 97% |
| AAU0306A | 880129-82-8 | Azido-PEG6-CH2COOH | 500mg | 1g | 98% |
| AAU0307A | 1214319-92-2 | Azido-PEG8-acid | 100mg | 200mg | 98% |
| AAU0308A | 217180-81-9 | Azido-PEG5-CH2CO2H | 250mg | 500mg | 98% |
| AAU0309A | 857891-82-8 | Azido-PEG8-amine | 250mg | 500mg | 97% |
| AAU0310A | 5961-83-1 | Bis-PEG1-acid | 250mg | 500mg | 98% |
| AAU0311A | 19364-66-0 | Bis-PEG2-acid | 250mg | 500mg | 97% |
| AAU0312A | 2411681-88-2 | Thalidomide-O-PEG4-NHS ester | 250mg | 500mg | 97% |
| AAU0313A | 82209-36-7 | Amino-PEG8-amine | 100mg | 200mg | 98% |
| AAU0314A | 1263045-16-4 | Mal-amido-PEG4-acid | 500mg | 1g | 97% |
| AAU0315A | 756525-99-2 | Mal-amido-PEG4-NHS ester | 100mg | 200mg | 98% |
| AAU0316A | 139338-72-0 | Fmoc-amino-PEG3-CH2COOH | 2g | 4g | 97% |
| AAU0317A | 252881-76-8 | Biotin-PEG3-acid | 1g | 2g | 95% |
| AAU0318A | 1381861-91-1 | Bromo-PEG2-C2-Boc | 1g | 2g | 97% |
| AAU0319A | 1292268-13-3 | N-Boc-PEG7-alcohol | 5g | 10g | 97% |
| AAU0320A | 1334286-77-9 | Hydroxy-PEG2-acid | 250mg | 500mg | 97% |
| AAU0321A | 1036204-60-0 | Propargyl-PEG5-OH | 250mg | 500mg | 95% |
| AAU0322A | 2250216-93-2 | Boc-NH-PEG3-NHS ester | 1g | 2g | 97% |
| AAU0323A | 1314378-14-7 | Fmoc-PEG4-NHS ester | 1g | 2g | 98% |
| AAU0324A | 1431618-70-0 | Biotin-PEG3-Mal | 100mg | 200mg | 97% |
| AAU0325A | 912849-73-1 | Azido-PEG10-amine | 1g | 2g | 97% |
| AAU0326A | 157759-50-7 | Bromo-PEG1-CH2-Boc | 1g | 2g | 97% |
| AAU0327A | 134179-38-7 | Amino-PEG3-C2-Azido | 100mg | 200mg | 97% |
| AAU0328A | 778596-26-2 | Hydroxy-PEG10-Boc | 1g | 2g | 97% |
| AAU0329A | 57641-67-5 | Br-PEG3-OH | 250mg | 500mg | 98% |
| AAU0330A | 189808-70-6 | NH2-PEG3-C1-Boc | 1g | 2g | 98% |
| AAU0331A | 7218-43-1 | Propargyl-PEG2-OH | 250mg | 500mg | 95% |
| AAU0332A | 1056024-94-2 | N3-PEG3-CH2CH2COOH | 5g | 10g | 98% |
| AAU0333A | 359860-27-8 | Amine-PEG3-Biotin | 100mg | 200mg | 97% |
| AAU0334A | 1537892-36-6 | Mal-PEG3-NHS ester | 500mg | 1g | 98% |
| AAU0335A | 1260092-44-1 | Boc-NH-PEG1-CH2CH2COOH | 5g | 10g | 97% |
| AAU0336A | 85141-94-2 | Br-PEG4-OH | 1g | 2g | 97% |
| AAU0337A | 352439-37-3 | NH2-PEG8-OH | 1g | 2g | 97% |
| AAU0338A | 141282-35-1 | Amino-PEG5-CH2COOH | 0.1g | 0.2g | 98% |
| AAU0339A | 635287-26-2 | Fmoc-NH-PEG5-CH2COOH | 0.25g | 0.5g | 97% |
| AAU0340A | 867062-95-1 | Fmoc-NH-PEG3-CH2CH2COOH | 100mg | 200mg | 98% |
| AAU0341A | 1052207-59-6 | Boc-NH-PEG8-CH2CH2NH2 | 1g | 2g | 98% |
| AAU0342A | 31255-26-2 | Bromo-PEG3-bromide | 1g | 2g | 98% |
| AAU0343A | 24345-74-2 | Azido-PEG1-azide | 100mg | 200mg | 98% |
| AAU0344A | 1325208-25-0 | Mal-PEG4-NHS ester | 250mg | 500mg | 97% |
| AAU0345A | 516493-93-9 | Azido-PEG5-amine | 1g | 2g | 97% |
| AAU0346A | 1374666-32-6 | Mal-PEG2-acid | 100mg | 200mg | 97% |
| AAU0347A | 1013921-36-2 | Propargyl-PEG4-amine | 250mg | 500mg | 97% |
| AAU0348A | 1347750-75-7 | Boc-N-amido-PEG3-acid | 1g | 2g | 97% |
| AAU0349A | 72236-26-1 | Amino-PEG5-amine | 0.25g | 0.5g | 97% |
| AAU0350A | 332941-25-0 | Amino-PEG7-amine | 0.25g | 0.5g | 98% |
| AAU0351A | 1517-05-1 | Azido-PEG1 | 5g | 10g | 97% |
| AAU0352A | 945633-30-7 | Biotin-PEG2-CH2CH2N3 | 50mg | 100mg | 97% |
| AAU0353A | 65869-63-8 | Bis-PEG2-NHS ester | 100mg | 200mg | 97% |
| AAU0354A | 206265-98-7 | Boc-NH-PEG7-NH2 | 100mg | 200mg | 97% |
| AAU0355A | 721431-18-1 | Biotin-PEG4-acid | 50mg | 100mg | 97% |
| AAU0356A | 1027371-75-0 | m-PEG1-NHS ester | 1g | 2g | 97% |
| AAU0357A | 110429-45-3 | m-PEG4-Br | 5g | 10g | 97% |
| AAU0358A | 782475-37-0 | Br-PEG3-C2-Boc | 1g | 2g | 97% |
| AAU0359A | 784105-33-5 | Amino-PEG3-C2-acid | 1g | 2g | 97% |
| AAU0360A | 530151-56-5 | Bromo-PEG2-C2-azide | 1g | 2g | 97% |
| AAU0361A | 905954-28-1 | NH2-PEG6-CH2CH2COOH | 1g | 2g | 97% |
| AAU0362A | 195071-49-9 | Amino-PEG4-CH2COOH | 2g | 4g | 97% |
| AAU0363A | 2365309-92-6 | Cl-PEG6-acid | 100mg | 200mg | 98% |
| AAU0364A | 1137109-21-7 | Mal-amido-PEG6-NHS ester | 100g | 200g | 97% |
| AAU0365A | 936917-36-1 | Iodo-PEG4-N3 | 500mg | 1g | 97% |
| AAU0366A | 85030-56-4 | m-PEG4-Amine | 250mg | 500mg | 97% |
| AAU0367A | 869718-81-0 | m-PEG8-Amine | 1g | 2g | 97% |
| AAU0368A | 1702356-19-1 | ENdo-BCN-PEG4-NHS ester | 25mg | 50mg | 97% |
| AAU0369A | 1058691-77-2 | m-PEG6-CH2CH2CHO | 100mg | 200mg | 97% |
Seebio supplies G-Kg grade protein drug intermediates
| Protein Drug Intermediates | Seebio Code | CAS No. | Name | Packsize |
| growth hormone side chain | AAU0178A | N/A | TZ-Ste-SO2-nBu-AEEA-Glu(OH)-Glu(OH)-AEEA-Lys(OH)-C | 1g, 5g; 1kg |
| AAU0179A | N/A | HO-Ste-CYH-Glu(OH)-Glu(OH)-AEEEEA-Mal | 1g, 5g; 1kg | |
| Tirzepatide Side Chain | AAU0180A | 1188328-37-1 | OtBu-Ara-Glu(AEEA-AEEA-OH)-OtBu | 1g, 5g; 1kg |
| Semaglutide Side Chain | AAU0181A | 1169630-40-3 | (S)-22-(carboxy)-1-((2,5-dioxocyclopentyl)oxy)-1,10,19,24-tetraoxo-3,6,12,15-tetraxa Oxa-9,18,23-azatetradecane-41-acid | 1g, 5g; 1kg |
| AAU0182A | 1118767-16-0 | tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu | 1g, 5g; 1kg | |
| AAU0183A | 1118767-15-9 | tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu | 1g, 5g; 1kg | |
| AAU0184A | N/A | tBuO-Ste-Glu(AEEA-AEEA-ONa)-OtBu | 1g, 5g; 1kg | |
| AAU0185A | 4871-70-5 | Octadecanedioic acid | 1g, 5g; 1kg | |
| AAU0186A | 843666-40-0 | Octadecanedioic acid Mono-tert-butyl ester | 1g, 5g; 1kg | |
| AAU0187A | 134978-97-5 | AEEA | 1g, 5g; 1kg | |
| AAU0188A | 1143516-05-5 | AEEA-AEEA | 1g, 5g; 1kg | |
| AAU0189A | 166108-71-0 | Fmoc-AEEA | 1g, 5g; 1kg | |
| AAU0190A | N/A | Fmoc-PEG3-acetic acid | 1g, 5g; 1kg | |
| AAU0191A | 2061897-68-3 | Boc-His(Trt)-Aib-OH | 1g, 5g; 1kg | |
| AAU0192A | N/A | Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH | 1g, 5g; 1kg | |
| AAU0193A | 1662688-20-1 | Fmoc-Lys(tBuO-Ste-Glu(AEEA-AEEA)-OtBu)-OH | 1g, 5g; 1kg | |
| AAU0194A | N/A | tBuO-Ste-Glu(AEEA-AEEA-Glu)-OtBu | 1g, 5g; 1kg | |
| Liraglutide Side Chain | AAU0195A | 204521-63-1 | Pal-Glu(OSu)-OtBu | 1g, 5g; 1kg |
| AAU0196A | 57078-98-5 | D-Pal-Glu(OSu)-OtBu | 1g, 5g; 1kg | |
| AAU0197A | N/A | L-HO-Pal-Lys(OSu)-OH | 1g, 5g; 1kg | |
| AAU0198A | 294855-91-7 | L-Pal-Glu(OSu)-OH | 1g, 5g; 1kg | |
| AAU0199A | N/A | L-Pal-Glu(OH)-OtBu | 1g, 5g; 1kg | |
| AAU0200A | N/A | 2L-HO-Pal-Glu(OSu)-OtBu | 1g, 5g; 1kg | |
| Insulin degludec Side Chain | AAU0201A | N/A | L-HO-Pal-Glu(OSu)-OH | 1g, 5g; 1kg |
| AAU0202A | N/A | L-tBuO-Pal-Glu(OSu)-OtBu | 1g, 5g; 1kg | |
| AAU0203A | N/A | L-tBuO-Pal-Glu(OSu)-OH | 1g, 5g; 1kg | |
| Insulin detemir Side Chain | AAU0204A | 69888-86-4 | N-succinimidyl myristic acid | 1g, 5g; 1kg |
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